Evidence map›Paper›PMID 21714745›Full record

Trial reportNeuropsychological rehabilitation2011

Changes in frontal-parietal activation and math skills performance following adaptive number sense training: preliminary results from a pilot study.

Shelli R Kesler, Kristen Sheau, Della Koovakkattu, Allan L Reiss

Open access · greenAbstract readClinical Trial
In one paragraph

Trial report in Neuropsychological rehabilitation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. A meta-analysis of math performance in Turner syndrome.Developmental medicine and child neurology · 2016
    Pooled it
  4. Trial
  5. Trial
  6. Review
  7. Article
  8. Article
  9. Article
  10. Brain sciences · 2021
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Aberrant parietal cortex developmental trajectories in girls with Turner syndrome and related visual-spatial cognitive development: a preliminary study.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014
    Article
  16. Cognition and behavior in Turner syndrome: a brief review.Pediatric endocrinology reviews : PER · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shelli R KeslerCenter for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA. skesler@stanford.edu
Kristen Sheau
Della Koovakkattu
Allan L Reiss
Stanford University · US

Funding

Gene, Brain and Behavior in Turner SyndromeR01HD049653 · NICHD · STANFORD UNIVERSITY · PI REISS, ALLAN L · 2006 to 2016
$6.0M
NICHD NIH HHS R01 HD049653
6 · The paper itself

Abstract

Number sense is believed to be critical for math development. It is putatively an implicitly learned skill and may therefore have limitations in terms of being explicitly trained, particularly in individuals with altered neurodevelopment. A case series study was conducted using an adaptive, computerised programme that focused on number sense and general problem-solving skills. The study was designed to investigate training effects on performance as well as brain function in a group of children with Turner syndrome who are at risk for math difficulties and altered development of math-related brain networks. Standardised measurements of math and math-related cognitive skills as well as functional magnetic resonance imaging (fMRI) were used to assess behavioural and neurobiological outcomes following training. Participants demonstrated significantly increased basic math skills, including number sense, and calculation as well as processing speed, cognitive flexibility and visual-spatial processing skills. With the exception of calculation, increased scores also were clinically significant (i.e., recovered) based on reliable change analysis. Participants additionally demonstrated significantly increased bilateral parietal lobe activation and decreased frontal-striatal and mesial temporal activation following the training programme. These findings show proof of concept for an accessible training approach that may be potentially associated with improved number sense, math and related skills, as well as functional changes in math-related neural systems, even among individuals at risk for altered brain development.

Indexed as

Mathematical ConceptsTreatment OutcomeAdolescentAptitudeBrainBrain MappingChildCognitionCognitive Behavioral TherapyFemaleHumansNeural PathwaysNeuropsychological TestsPilot ProjectsPsychomotor PerformanceTherapy, Computer-Assisted

Identifiers

PMID21714745
PMCPMC3152634
OpenAlexW2068437480

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.