ArticleJournal of the American Chemical Society2011
Luminescent gold nanoparticles with pH-dependent membrane adsorption.
Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 192 citations in OpenAlex.
- Ligand-dependent pharmacokinetic modulation via copper doping in ultrasmall gold nanoparticles.Materials today. Bio · 2026Article
- Lithium-Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- pH-Responsive Self-Assembly of Renal-Clearable Nanoparticles in the Kidneys: One Assembly per Endosome.Journal of the American Chemical Society · 2025Article
- Application of gold nanoclusters in fluorescence sensing and biological detection.Analytical and bioanalytical chemistry · 2024Review
- Opportunities and Challenges in the Synthesis of Noble Metal Nanoparticles via the Chemical Route in Microreactor Systems.Micromachines · 2024Review
- Biological Interaction and Imaging of Ultrasmall Gold Nanoparticles.Nano-micro letters · 2023Review
- Next-generation engineered nanogold for multimodal cancer therapy and imaging: a clinical perspectives.Journal of nanobiotechnology · 2022Review
- Biomolecular interactions of ultrasmall metallic nanoparticles and nanoclusters.Nanoscale advances · 2021Review
- Green Synthesis of Luminescent Gold-Zinc Oxide Nanocomposites: Cell Imaging and Visible Light-Induced Dye Degradation.Frontiers in chemistry · 2021Article
- NIR multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl-glutathione-coated gold nanoparticles.Scientific reports · 2020Article
- Controlling evolution of protein corona: a prosperous approach to improve chitosan-based nanoparticle biodistribution and half-life.Scientific reports · 2020Article
- Glutathione-capped CuO nanoparticles for the determination of cystine using resonance Rayleigh scattering spectroscopy.Mikrochimica acta · 2020Article
- A sensitive and specific nanosensor for monitoring extracellular potassium levels in the brain.Nature nanotechnology · 2020Article
- Augmented interaction of multivalent arginine coated gold nanoclusters with lipid membranes and cells.RSC advances · 2020Article
- X-ray tomography shows the varying three-dimensional morphology of gold nanoaggregates in the cellular ultrastructure.Nanoscale advances · 2019Article
- Probing the biological obstacles of nanomedicine with gold nanoparticles.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2019Review
- Renal Clearable Luminescent Gold Nanoparticles: From the Bench to the Clinic.Angewandte Chemie (International ed. in English) · 2019Review
- The synthesis and characterization of glutathione-modified superparamagnetic iron oxide nanoparticles and their distribution in rat brains after injection in substantia nigra.Journal of materials science. Materials in medicine · 2018Article
- A fluorescent sensor constructed from nitrogen-doped carbon nanodots (N-CDs) for pH detection in synovial fluid and urea determination.RSC advances · 2018Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
pH regulates many cellular processes and is also an indicator of disease progression. Therefore, pH-responsive materials often serve as either tools in the fundamental understanding of cell biology or medicine for disease diagnosis and therapy. While gold nanoparticles have broad biomedical applications, very few of them exhibit pH-dependent interactions with live cells in a native biological environment due to nonspecific serum protein adsorption. Herein, we report that by coating luminescent gold nanoparticles with a natural peptide, glutathione, and the simplest stable aminothiol, cysteamine, we enabled the nanoparticles to exhibit not only high resistance to serum protein adsorption but also pH-dependent adsorption onto live cell membranes in the presence of serum proteins. Incorporating this pH-dependent membrane adsorption behavior into gold nanoparticles could potentially catalyze new biomedical applications of metal nanoparticles in the fundamental understanding of biological processes as well as disease diagnosis and therapy, where pH changes are involved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.