ArticleJournal of the American Chemical Society2011
Proton coupled electron transfer and redox-active tyrosine Z in the photosynthetic oxygen-evolving complex.
Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 45 citations in OpenAlex.
- Highly Enantioselective Construction of Oxazolidinone Rings via Enzymatic C(spACS catalysis · 2025Article
- Proton-coupled electron transfer across benzimidazole bridges in bioinspired proton wires.Chemical science · 2020Article
- Transition State Asymmetry in C-H Bond Cleavage by Proton-Coupled Electron Transfer.Journal of the American Chemical Society · 2019Article
- Structure and Function of Tryptophan-Tyrosine Dyads in Biomimetic β Hairpins.The journal of physical chemistry. B · 2019Article
- Calcium, conformational selection, and redox-active tyrosine YZ in the photosynthetic oxygen-evolving cluster.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Concerted One-Electron Two-Proton Transfer Processes in Models Inspired by the Tyr-His Couple of Photosystem II.ACS central science · 2017Article
- Detection of an intermediary, protonated water cluster in photosynthetic oxygen evolution.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Reversible phenol oxidation and reduction in the structurally well-defined 2-Mercaptophenol-α₃C protein.Biochemistry · 2013Article
- Photochemical Tyrosine Oxidation with a Hydrogen-Bonded Proton Acceptor by Bidirectional Proton-Coupled Electron Transfer.Chemical science · 2012Article
- A hydrogen-bonding network plays a catalytic role in photosynthetic oxygen evolution.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Proton Coupled Electron Transfer and Redox Active Tyrosines: Structure and Function of the Tyrosyl Radicals in Ribonucleotide Reductase and Photosystem II.The journal of physical chemistry letters · 2012Article
- Proton-coupled electron transfer.Chemical reviews · 2007Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Proton coupled electron transfer (PCET) reactions play an essential role in many enzymatic processes. In PCET, redox-active tyrosines may be involved as intermediates when the oxidized phenolic side chain deprotonates. Photosystem II (PSII) is an excellent framework for studying PCET reactions, because it contains two redox-active tyrosines, YD and YZ, with different roles in catalysis. One of the redox-active tyrosines, YZ, is essential for oxygen evolution and is rapidly reduced by the manganese-catalytic site. In this report, we investigate the mechanism of YZ PCET in oxygen-evolving PSII. To isolate YZ(•) reactions, but retain the manganese-calcium cluster, low temperatures were used to block the oxidation of the metal cluster, high microwave powers were used to saturate the YD(•) EPR signal, and YZ(•) decay kinetics were measured with EPR spectroscopy. Analysis of the pH and solvent isotope dependence was performed. The rate of YZ(•) decay exhibited a significant solvent isotope effect, and the rate of recombination and the solvent isotope effect were pH independent from pH 5.0 to 7.5. These results are consistent with a rate-limiting, coupled proton electron transfer (CPET) reaction and are contrasted to results obtained for YD(•) decay kinetics at low pH. This effect may be mediated by an extensive hydrogen-bond network around YZ. These experiments imply that PCET reactions distinguish the two PSII redox-active tyrosines.
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