ArticleJournal of pediatric endocrinology & metabolism : JPEM2010
Does fat fuel the fire: independent and interactive effects of genetic, physiological, and environmental factors on variations in fat deposition and distribution across populations.
Article in Journal of pediatric endocrinology & metabolism : JPEM, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Inflammatory markers and bone mass in children with overweight/obesity: the role of muscular fitness.Pediatric research · 2020Article
- The associations between the changes in serum inflammatory markers and bone mineral accrual in boys with overweight and obesity during pubertal maturation: a 3-year longitudinal study in Estonian boys.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Serum interferon gamma concentration is associated with bone mineral density in overweight boys.Journal of endocrinological investigation · 2014Article
- The relationship between bioactive components in breast milk and bone mass in infants.BoneKEy reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Markers of inflammation (MOI) have been reported to influence bone health in adults, with reports of inverse associations. Adipose has also been linked to bone. In children, the interrelationships are unclear. The objective of this study was to evaluate the relationship between MOI (i.e. CRP, TNFR2, IL-6) and bone mineral content (BMC) and determine the contribution of fat deposition/distribution in children. Forty-nine children (59% male) 7-12 y participated. Body composition was evaluated by DXA, and MOI and insulin sensitivity (S(I)) were obtained during an IVGTT. Multiple linear regression was used for analyses. TNFR2 was inversely associated with BMC. In boys, TNFR2 was inversely associated with BMC, and in girls IL-6 was inversely associated with BMC, and total and percent fat influenced the relationships. Our results suggest a potential inhibitory role of inflammation on bone as well as a negative impact of adiposity. Future investigations are warranted to further investigate these relationships.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.