ArticleMagnetic resonance in medicine2012
Effect of intercompartmental water exchange on the apparent myelin water fraction in multiexponential T2 measurements of rat spinal cord.
Article in Magnetic resonance in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Pooled it
- Quantitative Comparison of Multi-Echo Spin Echo and Multi-Echo Gradient Echo Myelin Water Imaging in a Panel of Mbp Enhancer-Edited Mouse Lines.Magnetic resonance in medicine · 2026Article
- Field Strength-Dependent White Matter RMagnetic resonance in medicine · 2026Article
- Impact of tissue sample preparation methods on myelin-sensitive quantitative MR imaging.Magnetic resonance in medicine · 2025Article
- Myelin water and tensor-valued diffusion imaging: (How) are they related?Magnetic resonance in medicine · 2025Article
- Evaluation of diffusion time-dependent changes in radial diffusivity as a surrogate for axon diameter.Magnetic resonance in medicine · 2025Article
- Three-Dimensional Efficient Myelin-Weighted Imaging Utilizing Direct Visualization of Short Transverse Relaxation Time Component (ViSTa).Human brain mapping · 2025Article
- Impact of Tissue Sample Preparation Methods on Myelin-Sensitive Quantitative MR Imaging.bioRxiv : the preprint server for biology · 2025Article
- Interplay between MRI-based axon diameter and myelination estimates in macaque and human brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Improved myelin water imaging using BImaging neuroscience (Cambridge, Mass.) · 2024Article
- Measuring water exchange on a preclinical MRI system using filter exchange and diffusion time dependent kurtosis imaging.Magnetic resonance in medicine · 2023Article
- Mitigating the impact of flip angle and orientation dependence in single compartment R2* estimates via 2-pool modeling.Magnetic resonance in medicine · 2023Article
- Impact of the acquisition protocol on the sensitivity to demyelination and axonal loss of clinically feasible DWI techniques: a simulation study.Magma (New York, N.Y.) · 2021Article
- A simple estimate of axon size with diffusion MRI.NeuroImage · 2021Article
- Towards in vivo g-ratio mapping using MRI: Unifying myelin and diffusion imaging.Journal of neuroscience methods · 2021Review
- An atlas for human brain myelin content throughout the adult life span.Scientific reports · 2021Article
- Myelin water fraction estimation using small-tip fast recovery MRI.Magnetic resonance in medicine · 2020Article
- Quantitative age-dependent differences in human brainstem myelination assessed using high-resolution magnetic resonance mapping.NeuroImage · 2020Article
- Adult brain aging investigated using BMC-mcDESPOT-based myelin water fraction imaging.Neurobiology of aging · 2020Article
- Estimation of cellular-interstitial water exchange in dynamic contrast enhanced MRI using two flip angles.NMR in biomedicine · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The myelin water fraction has been used as a quantitative measure of the amount of myelin present in tissue. However, recent work has suggested that intercompartmental exchange of water between myelin and nonmyelin compartments may cause the myelin water fraction to underestimate the true myelin content of tissue. In this work, multiexponential T(2) experiments were performed in vivo within the rat spinal cord, and a wide variation of the myelin water fraction (10-35%) was measured within four rat spinal cord tracts with similar myelin content. A numerical simulation based upon segmented histology images was used to quantitatively account for T(2) variations between tracts. The model predicts that a difference in exchange between the four spinal cord tracts, mediated by a difference in the average axon radius and myelin thickness, is sufficient to account for the variation in myelin water fraction measured in vivo.
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Registered trials
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