ReviewAdvances in experimental medicine and biology2011
Spatio-temporal signaling in mast cells.
Review in Advances in experimental medicine and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Integrins and tetraspanins mediate CD36-actin coupling and regulate CD36 organization and signaling.The Journal of cell biology · 2026Article
- Investigation of CD36 interactome provides insights into multimolecular complexes necessary for anti-angiogenic signalling.bioRxiv : the preprint server for biology · 2025Article
- Review
- Regulation of Trafficking and Signaling of the High Affinity IgE Receptor by FcεRIβ and the Potential Impact of FcεRIβ Splicing in Allergic Inflammation.International journal of molecular sciences · 2022Review
- Multifunctional regulation of VAMP3 in exocytic and endocytic pathways of RBL-2H3 cells.Frontiers in immunology · 2022Article
- Anaphylactic Degranulation of Mast Cells: Focus on Compound Exocytosis.Journal of immunology research · 2019Review
- Immuno-receptors: from recognition to signaling and function.European biophysics journal : EBJ · 2018Review
- Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics.Molecular biology of the cell · 2017Article
- Allergen Valency, Dose, and FcεRI Occupancy Set Thresholds for Secretory Responses to Pen a 1 and Motivate Design of Hypoallergens.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Article
- Extending rule-based methods to model molecular geometry and 3D model resolution.BMC systems biology · 2016Article
- Article
- Optimal aggregation of FcεRI with a structurally defined trivalent ligand overrides negative regulation driven by phosphatases.ACS chemical biology · 2014Article
- Single-cell measurements of IgE-mediated FcεRI signaling using an integrated microfluidic platform.PloS one · 2013Article
- Mathematical simulation of membrane protein clustering for efficient signal transduction.Annals of biomedical engineering · 2012Review
- Regulation from within: the cytoskeleton in transmembrane signaling.Trends in cell biology · 2012Review
- Mast cell adenosine receptors function: a focus on the a3 adenosine receptor and inflammation.Frontiers in immunology · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
This chapter summarizes the evidence for localized signaling domains in mast cells and basophils, with a particular focus on the high affinity IgE receptor, FcεRI and its crosstalk with other membrane proteins. It is noteworthy that a literature spanning 30 years established the FcεRI as a model receptor for studying activation-induced changes in receptor diffusion and lipid raft association. Now a combination of high resolution microscopy methods, including immunoelectron microscopy and sophisticated fluorescence-based techniques, provide new insight into the nanoscale spatial and temporal aspects of receptor topography on the mast cell plasma membrane. Physical crosslinking of FcεRI with multivalent ligands leads to formation of IgE receptor clusters, termed "signaling patches," that recruit downstream signaling molecules. However, classes of receptors that engage solely withmono valent ligands can also form distinctive signaling patches. The dynamic relationships between receptor diffusion, aggregation state, clustering, signal initiation and signal strength are discussed in the context of these recent findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.