ArticleImmunogenetics2011
Reproductive tissue-specific expression profiling and genetic variation across a 19 gene bovine β-defensin cluster.
Article in Immunogenetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 39 citations in OpenAlex.
- Beta-defensin 126 (DEFB126) localization and expression in the sperms and male reproductive tract of the dromedary camel (Open veterinary journal · 2025Article
- Impact of β-defensin 103 (DEFB103) copy number variation on bull sperm parameters and post-insemination uterine gene expression.PloS one · 2025Article
- β-Defensin gene copy number variation in cattle.Royal Society open science · 2024Article
- Analysis of amplification and association polymorphisms in the bovine beta-defensin 129 (BBD129) gene revealed its function in bull fertility.Scientific reports · 2022Article
- Molecular Identification and Antibacterial Activity Analysis of Blue Fox (Animals : an open access journal from MDPI · 2021Article
- Article
- Improved filtration method to isolate pure populations of primary bovine endometrial epithelial and stromal cells for immunological studies.Veterinary research communications · 2020Article
- Unusual interplay of contrasting selective pressures on β-defensin genes implicated in male fertility of the Buffalo (Bubalus bubalis).BMC evolutionary biology · 2019Article
- Characterization of the β-defensin genes in giant panda.Scientific reports · 2018Article
- β-Defensins: Farming the Microbiome for Homeostasis and Health.Frontiers in immunology · 2018Review
- A dual targeted β-defensin and exome sequencing approach to identify, validate and functionally characterise genes associated with bull fertility.Scientific reports · 2017Article
- Comparative genomic identification and validation of β-defensin genes in the Ovis aries genome.BMC genomics · 2017Article
- Characterization of the antimicrobial peptide family defensins in the Tasmanian devil (Sarcophilus harrisii), koala (Phascolarctos cinereus), and tammar wallaby (Macropus eugenii).Immunogenetics · 2017Article
- Detection and validation of structural variations in bovine whole-genome sequence data.Genetics, selection, evolution : GSE · 2017Article
- Sperm-Coating Beta-Defensin 126 Is a Dissociation-Resistant Dimer Produced by Epididymal Epithelium in the Bovine Reproductive Tract.Biology of reproduction · 2016Article
- Cauda Epididymis-Specific Beta-Defensin 126 Promotes Sperm Motility but Not Fertilizing Ability in Cattle.Biology of reproduction · 2016Article
- Genome-level identification, gene expression, and comparative analysis of porcine ß-defensin genes.BMC genetics · 2012Article
- Constraints on haplotype structure and variable gene frequencies suggest a functional hierarchy within cattle MHC class I.Immunogenetics · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
β-defensins are small cationic peptides, with potent immunoregulatory and antimicrobial activity which are produced constitutively and inducibly by eukaryotic cells. This study profiles the expression of a cluster of 19 novel defensin genes which spans 320 kb on chromosome 13 in Bos taurus. It also assesses the genetic variation in these genes between two divergently selected cattle breeds. Using quantitative real-time PCR (qRT-PCR), all 19 genes in this cluster were shown to be expressed in the male genital tract and 9 in the female genital tract, in a region-specific manner. These genes were sequenced in Norwegian Red (NR) and Holstein-Friesian (HF) cattle for population genetic analysis. Of the 17 novel single nucleotide polymorphisms (SNPs) identified, 7 were non-synonymous, 6 synonymous and 4 outside the protein coding region. Significant frequency differences in SNPs in bovine β-defensins (BBD) 115, 117, 121, and 122 were detected between the two breeds, which was also reflected at the haplotype level (P<0.05). There was clear segregation of the haplotypes into two blocks on chromosome 13 in both breeds, presumably due to historical recombination. This study documents genetic variation in this β-defensin gene cluster between Norwegian Red and Holstein-Friesian cattle which may result from divergent selection for production and fertility traits in these two breeds. Regional expression in the epididymis and fallopian tube suggests a potential reproductive-immunobiology role for these genes in cattle.
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