Evidence map›Paper›PMID 21713429›Full record

ArticleInfection2011

Coxiella burnetii causing haemophagocytic syndrome: a rare complication of an unusual pathogen.

P Harris, R Dixit, R Norton

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Infection, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Bacteria-Associated Cytokine Storm Syndrome.Advances in experimental medicine and biology · 2024
    Review
  3. Zoonotic Bacterial Infections Triggering Cytokine Storm Syndrome.Advances in experimental medicine and biology · 2024
    Review
  4. Article
  5. Article
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  7. Article
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

P HarrisPathology Queensland, Townsville Hospital, Douglas, QLD 4811, Australia. patrick.harris@hnehealth.nsw.gov.au
R Dixit
R Norton
Townsville Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe an unusual presentation of Q fever with associated haemophagocytic syndrome, confirmed by bone marrow aspirate, Q fever polymerase chain reaction (PCR) and serological testing. Clinical recovery was observed after the commencement of doxycycline with normalisation of the patient's full blood count and serum biochemistry. Serial monitoring of the Q fever serology revealed the subsequent development of sustained high phase 1 IgG antibodies, suggestive of chronic Q fever. Although many infectious aetiologies have been associated with haemophagocytosis, Q fever has only rarely been described in this context. The diagnosis of Q fever is often overlooked, especially when the presentation is atypical. We describe how the use of PCR testing significantly shortened the interval to definitive diagnosis and helped elucidate the underlying cause of the patient's haematological disorder.

Indexed as

Antibodies, BacterialBone MarrowCoxiella burnetiiHistocytochemistryHumansImmunoglobulin GLymphohistiocytosis, HemophagocyticMaleMiddle AgedPolymerase Chain ReactionQ FeverSerologic TestsAntibodies, BacterialImmunoglobulin G

Identifiers

PMID21713429
OpenAlexW2072613009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.