ArticleFrontiers in systems neuroscience2011
Distribution of tyrosine hydroxylase-expressing interneurons with respect to anatomical organization of the neostriatum.
Article in Frontiers in systems neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Comparative analysis of the cellular landscape in mammalian striatum.Nature communications · 2026Article
- Altered striosome-matrix distribution and activity of striatal cholinergic interneurons in a model of autism-linked repetitive behaviors.Molecular psychiatry · 2026Article
- Comprehensive 3D mapping reveals distinct spatial gradients of SST, PV, and TH interneurons across the mouse caudoputamen.bioRxiv : the preprint server for biology · 2026Article
- Comprehensive 3D mapping reveals distinct spatial gradients of genetically-identified SST, PV, and TH interneurons across the mouse caudoputamen.Frontiers in cellular neuroscience · 2026Article
- Tyrosine Hydroxylase-Positive Nucleus Accumbens Neurons Influence Delay Discounting in a Mouse T-Maze Task.eNeuro · 2024Article
- Ivermectin increases striatal cholinergic activity to facilitate dopamine terminal function.Cell & bioscience · 2024Article
- Striatal Neurons Partially Expressing a Dopaminergic Phenotype: Functional Significance and Regulation.International journal of molecular sciences · 2022Article
- Neuropathological investigation of patients with prolonged anorexia nervosa.Psychiatry and clinical neurosciences · 2022Article
- Loss of striatal tyrosine-hydroxylase interneurons impairs instrumental goal-directed behavior.The European journal of neuroscience · 2019Article
- A Novel Type of Neuron Within the Dorsal Striatum.Frontiers in neural circuits · 2019Article
- Diversity of Interneurons in the Dorsal Striatum Revealed by Single-Cell RNA Sequencing and PatchSeq.Cell reports · 2018Article
- Differential electrophysiological properties of D1 and D2 spiny projection neurons in the mouse nucleus accumbens core.Physiological reports · 2018Article
- Identification and Characterization of a Novel Spontaneously Active Bursty GABAergic Interneuron in the Mouse Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Differential processing of thalamic information via distinct striatal interneuron circuits.Nature communications · 2017Article
- Dopaminergic and cholinergic modulation of striatal tyrosine hydroxylase interneurons.Neuropharmacology · 2015Article
- Are striatal tyrosine hydroxylase interneurons dopaminergic?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Anatomical and electrophysiological changes in striatal TH interneurons after loss of the nigrostriatal dopaminergic pathway.Brain structure & function · 2015Article
- Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons.Molecular therapy. Methods & clinical development · 2015Article
- Early minocycline treatment prevents a decrease in striatal dopamine in an SIV model of HIV-associated neurological disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Article
- Distribution of GABAergic interneurons and dopaminergic cells in the functional territories of the human striatum.PloS one · 2012Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We have recently shown in vitro that striatal tyrosine hydroxylase-expressing interneurons identified in transgenic mice by expression of enhanced green fluorescent protein (TH-eGFP) display electrophysiological profiles that are distinct from those of other striatal interneurons. Furthermore, striatal TH-eGFP interneurons show marked diversity in their electrophysiological properties and have been divided into four distinct subtypes. One question that arises from these observations is whether striatal TH-eGFP interneurons are distributed randomly, or obey some sort of organizational plan as has been shown to be the case with other striatal interneurons. An understanding of the striatal TH-eGFP interneuronal patterning is a vital step in understanding the role of these neurons in striatal functioning. Therefore, in the present set of studies the location of electrophysiologically identified striatal TH-eGFP interneurons was mapped. In addition, the distribution of TH-eGFP interneurons with respect to the striatal striosome-matrix compartmental organization was determined using μ-opioid receptor (MOR) immunofluorescence or intrinsic TH-eGFP fluorescence to delineate striosome and matrix compartments. Overall, the distribution of the different TH-eGFP interneuronal subtypes did not differ in dorsal versus ventral striatum. However, striatal TH-eGFP interneurons were found to be mostly in the matrix in the dorsal striatum whereas a significantly higher proportion of these neurons was located in MOR-enriched domains of the ventral striatum. Further, the majority of striatal TH-eGFP interneurons was found to be located within 100 μm of a striosome-matrix boundary. Taken together, the current results suggest that TH-eGFP interneurons obey different organizational principles in dorsal versus ventral striatum, and may play a role in communication between striatal striosome and matrix compartments.
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