ArticleFrontiers in cellular neuroscience2011
Understanding the molecular diversity of GABAergic synapses.
Article in Frontiers in cellular neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Molecular and Cellular Mechanisms of Synaptogenesis and Synaptic Refinement During Cerebellar Circuit Formation.International journal of molecular sciences · 2026Review
- Genomic and ancestral variations linked to the development of post-acute sequelae of SARS-CoV-2 infection in Indian populations.Frontiers in genetics · 2025Article
- Nano-organization of spontaneous GABAergic transmission directs its autonomous function in neuronal signaling.Cell reports · 2022Article
- Neurexins and their ligands at inhibitory synapses.Frontiers in synaptic neuroscience · 2022Review
- Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity.Cell reports · 2021Article
- Multiple synaptic connections into a single cortical pyramidal cell or interneuron in the anterior cingulate cortex of adult mice.Molecular brain · 2021Article
- Differentiation and Characterization of Excitatory and Inhibitory Synapses by Cryo-electron Tomography and Correlative Microscopy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development.Neuron · 2017Article
- Orbitofrontal Neuroadaptations and Cross-Species Synaptic Biomarkers in Heavy-Drinking Macaques.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Protein O-Mannosylation in the Murine Brain: Occurrence of Mono-O-Mannosyl Glycans and Identification of New Substrates.PloS one · 2016Article
- Enrichment of GABAA Receptor α-Subunits on the Axonal Initial Segment Shows Regional Differences.Frontiers in cellular neuroscience · 2016Article
- Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer.The Journal of comparative neurology · 2015Article
- Gephyrin: a master regulator of neuronal function?Nature reviews. Neuroscience · 2014Review
- Synaptic molecular imaging in spared and deprived columns of mouse barrel cortex with array tomography.Scientific data · 2014Article
- Shaping inhibition: activity dependent structural plasticity of GABAergic synapses.Frontiers in cellular neuroscience · 2014Review
- Plasma membrane transporters GAT-1 and GAT-3 contribute to heterogeneity of GABAergic synapses in neocortex.Frontiers in neuroanatomy · 2014Article
- Activity-dependent adaptations in inhibitory axons.Frontiers in cellular neuroscience · 2013Review
- Automated analysis of a diverse synapse population.PLoS computational biology · 2013Article
- Neuroligin 2 is expressed in synapses established by cholinergic cells in the mouse brain.PloS one · 2013Article
- Synaptic competition sculpts the development of GABAergic axo-dendritic but not perisomatic synapses.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GABAergic synapses exhibit a high degree of subcellular and molecular specialization, which contrasts with their apparent simplicity in ultrastructural appearance. Indeed, when observed in the electron microscope, GABAergic synapses fit in the symmetric, or Gray's type II category, being characterized by a relatively simple postsynaptic specialization. The inhibitory postsynaptic density cannot be readily isolated, and progress in understanding its molecular composition has lagged behind that of excitatory synapses. However, recent studies have brought significant progress in the identification of new synaptic proteins, revealing an unexpected complexity in the molecular machinery that regulates GABAergic synaptogenesis. In this article, we provide an overview of the molecular diversity of GABAergic synapses, and we consider how synapse specificity may be encoded by selective trans-synaptic interactions between pre- and postsynaptic adhesion molecules and secreted factors that reside in the synaptic cleft. We also discuss the importance of developing cataloguing tools that could be used to decipher the molecular diversity of synapses and to predict alterations of inhibitory transmission in the course of neurological diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.