ArticleLung India : official organ of Indian Chest Society2011
Can bronchial asthma be classified based on the immunological status?
Article in Lung India : official organ of Indian Chest Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Determination of sputum eosinophil count and serum absolute eosinophil count in patients with bronchial asthma and its correlation with disease severity and response to treatment.Journal of family medicine and primary care · 2023Article
- Examining changes in vascular function, arterial stiffness and systemic inflammation during hospitalization and recovery from an acute exacerbation of chronic obstructive pulmonary disease.Scientific reports · 2023Article
- Immunological Factors Associated with Adult Asthma in the Aseer Region, Southwestern Saudi Arabia.International journal of environmental research and public health · 2019Article
- Correlation of total serum immunoglobulin E level, sputum, and peripheral eosinophil count in assessing the clinical severity in bronchial asthma.Lung India : official organ of Indian Chest SocietyArticle
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Authors and funding
8 authors.
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Abstract
backgroundBronchial asthma is a chronic disorder of the airways. Bronchial asthma can be broadly categorized into atopic and nonatopic based on the immunological status, which may be helpful to plan appropriate treatment. In this study, the cytokine profile of the blood was estimated to evaluate the difference between the atopic and the nonatopic asthmatics.
aimThe aim was to document the differences in cytokine (IL-6, TNF-α, and IFN-γ) imbalance in asthmatics with high serum immunoglobulin E (IgE) levels compared to those with normal serum IgE. MATERIALS AND
methodsThirty confirmed bronchial asthmatics (17 men, 13 women) were included in this study. The serum levels of IgE, IFN-γ TNF-α, and IL-6 were measured using the enzyme-linked immunosorbent assay technique. They were divided into two groups based on serum IgE: asthmatics with normal serum IgE levels as group A (n = 7) and high IgE levels as group B (n = 23).
results: The differences in the mean values of IgE, TNF-α, and IFN-γ were statistically significant between the groups. These values were significantly higher in group B compared to group A. IL-6 was not significantly different between the groups. In group A, IL-6 was negatively correlated with IgE and IFN-γ. IgE and IFN-γ were positively correlated. In group B, IFN-γ and TNF-α showed a high correlation of +0.93.
conclusionTwo groups of asthmatics stratified according to their serum IgE levels were immunologically different showing different profiles of serum cytokine levels and the relationship between the cytokines.
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