ArticleEuropean journal of clinical nutrition2011
Vitamin D and parathyroid hormone in insulin resistance of abdominal obesity: cause or effect?
Article in European journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 34 citations in OpenAlex.
- Serum vitamin D concentration and anthropometric indicators of adiposity in adults without or with low dose statin users: a cross-sectional study.Journal of health, population, and nutrition · 2024Article
- Bioactive, full-length parathyroid hormone delivered using an adeno-associated viral vector.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- The predictive role of parathyroid hormone for non-alcoholic fatty liver disease based on invasive and non-invasive findings in candidates of bariatric surgery.Eating and weight disorders : EWD · 2022Article
- Article
- Seafood intake and the development of obesity, insulin resistance and type 2 diabetes.Nutrition research reviews · 2019Review
- The associations of vitamin D status and dietary calcium with the metabolic syndrome: an analysis of the Victorian Health Monitor survey.Public health nutrition · 2017Article
- Calcium and vitamin D in the regulation of energy balance: where do we stand?International journal of molecular sciences · 2014Review
- Factors determining the risk of the metabolic syndrome: is there a central role for adiponectin?European journal of clinical nutrition · 2013Review
- Plasma vitamin D and parathormone are associated with obesity and atherogenic dyslipidemia: a cross-sectional study.Cardiovascular diabetology · 2012Article
- Is vitamin D status relevant to metabolic syndrome?Dermato-endocrinology · 2012Article
- Calcium and vitamin D for obesity: a review of randomized controlled trials.European journal of clinical nutrition · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective was to examine whether there were causal links between vitamin D status, parathyroid hormone, insulin resistance (IR)/insulin sensitivity (IS) and the metabolic syndrome (MS). A total of 72 Caucasian men and women, aged 55.7 ± 7.57 years, with body mass index 33.4 ± 4.02 kg/m(2) and abdominal obesity, were assessed for IR/IS based on three commonly used indices before and after 12 weeks of supervised weight loss. During weight stability, though both lower intact parathyroid hormone (iPTH) and higher vitamin D were independently associated with greater IS/lower IR, this was consistent for iPTH across the surrogate measures tested. Higher iPTH, but not lower vitamin D, increased the risk of MS after adjustment for IR/IS. Weight loss resulted in significant reductions in percent fat (-2.83 ± 2.20%), waist (-9.26 ± 5.11 cm), improvements in all IS indices, reductions in MS and iPTH (-0.28 ± 1.17 pmol/l), but no increase in vitamin D (+2.19 ± 12.17 nmol/l). Following weight loss, ΔiPTH either predicted change in IR/IS or contributed to their variance by 4.1-8.9%. On adjustment for IR/IS, higher ΔiPTH did not significantly predict MS after weight loss, though the odds ratios for the effect were sizeable. The data are suggestive of an intrinsic inverse relationship between iPTH and IS in abdominally obese individuals, independent of vitamin D. There remains the possibility of a direct relationship between iPTH and MS.
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Registered trials
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