ArticleJournal of dental research2011
Lipopolysaccharide-induced pulpitis up-regulates TRPV1 in trigeminal ganglia.
Article in Journal of dental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
45 citing papers in PubMed, 94 citations in OpenAlex.
- No relevant modulation of TRPV1-mediated trigeminal pain by intranasal carbon dioxide in healthy humans.The journal of headache and pain · 2013Trial
- Redefining the Evolution of Pulpal Pathology: Inflammasomes as Central Integrative Hubs and Biological Switches Governing the Transition From Reversible to Irreversible Pulpal Inflammation Beyond Symptom-Based Classification.International endodontic journal · 2026Review
- The Interaction Between the Central Nervous System and Dental Tissues: Hypothetical Dental Interoception Inferred From Skeletal Interoception.Journal of oral rehabilitation · 2026Review
- Influence of occlusal reduction on postoperative pain following single-visit root canal treatment in mandibular molars: a randomized controlled trial.Restorative dentistry & endodontics · 2026Article
- MSC-derived small extracellular vesicles promote dental pulp repair by alleviating inflammation in pulpitis via AKT and p38 MAPK pathways.Stem cells (Dayton, Ohio) · 2026Article
- Tooth Pulp Afferents and Transient Receptor Potential (TRP) Ion Channels as Key Regulators of Pulp Homeostasis, Inflammation, and Pain.International journal of molecular sciences · 2025Review
- LPS-Induced Neuroinflammation Increases Serotonin-Evoked Activity of Trigeminal Afferents and Aggravates Mechanical Allodynia and Photophobic Behavior in Rat Migraine Model.International journal of molecular sciences · 2025Article
- Osteomodulin modulates the inflammatory responses via the interleukin-1 receptor 1/nuclear factor-κB signaling pathway in dental pulpitis.International journal of oral science · 2025Article
- Effect of TheraCal PT and Biodentine on inflammatory cell infiltration and hard tissue formation after pulpotomy in inflamed or healthy rat molars.Clinical oral investigations · 2025Article
- Mouse Model of Lipopolysaccharide (LPS)-Induced Pulpitis.Bio-protocol · 2025Article
- TRPV1-target drugs for the treatment of orofacial pain.Frontiers in pharmacology · 2025Review
- The anatomy, neurophysiology, and cellular mechanisms of intradental sensation.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- Rodent models for oral microbiome research: considerations and challenges- a mini review.Frontiers in oral health · 2024Review
- Effect of submucosal cryotherapy compared with steroids and NSAIDs injections on Substance P and Interleukin 6 pulpal release in experimentally induced pulpal inflammation in rabbits.Journal of applied oral science : revista FOB · 2024Article
- Dental Pulp Stem Cells and Current in vivo Approaches to Study Dental Pulp Stem Cells in Pulp Injury and Regeneration.Journal of bone metabolism · 2023Article
- Lipopolysaccharide-induced Trigeminal Ganglion Nerve Fiber Damage is Associated with Autophagy Inhibition.Current medical science · 2023Article
- Expression of Toll-like receptor 2, Dectin-1, and Osteopontin in murine model of pulpitis.Clinical oral investigations · 2023Article
- Wnt4 prevents apoptosis and inflammation of dental pulp cells induced by LPS by inhibiting the IKK/NF‑κB pathway.Experimental and therapeutic medicine · 2023Article
- Substance P aggravates ligature-induced periodontitis in mice.Frontiers in immunology · 2023Article
- Nociceptor Neurons Magnify Host Responses to Aggravate Periodontitis.Journal of dental research · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Tooth pain often accompanies pulpitis. Accumulation of lipopolysaccharides (LPS), a product of Gram-negative bacteria, is associated with painful clinical symptoms. However, the mechanisms underlying LPS-induced tooth pain are not clearly understood. TRPV1 is a capsaicin- and heat-gated nociceptive ion channel implicated in thermosensation and hyperalgesia under inflammation or injury. Although TRPV1 is expressed in pulpal afferents, it is not known whether the application of LPS to teeth modulates TRPV1 in trigeminal nociceptors. By assessing the levels of protein and transcript of TRPV1 in mouse trigeminal ganglia, we demonstrate that dentinal application of LPS increases the expression of TRPV1. Our results suggest that the up-regulation of TRPV1 in trigeminal nociceptors following bacterial infection could contribute to hyperalgesia under pulpitis conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.