ArticleThe Journal of biological chemistry2011
Acireductone dioxygenase 1 (ARD1) is an effector of the heterotrimeric G protein beta subunit in Arabidopsis.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- Methylthioadenosine-driven rewiring of sulfur assimilation lowers the methyl index and fertility in Arabidopsis.Journal of experimental botany · 2026Article
- Phosphorylation-activated G protein signaling stabilizes TCP14 and JAZ3 to repress JA signaling and enhance plant immunity.Molecular plant · 2025Article
- Proteomic profiling ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- A Genome-Wide Association Study Reveals the Genetic Mechanisms of Nutrient Accumulation in Spinach.Genes · 2024Article
- High-quality genome assembly of Huazhan and Tianfeng, the parents of an elite rice hybrid Tian-you-hua-zhan.Science China. Life sciences · 2022Article
- Protein-protein interactions in plant antioxidant defense.Frontiers in plant science · 2022Review
- Molecular Characterization of NDL1-AGB1 Mediated Salt Stress Signaling: Further Exploration of the Role ofCells · 2021Article
- Overexpression ofFrontiers in plant science · 2019Article
- G protein subunit phosphorylation as a regulatory mechanism in heterotrimeric G protein signaling in mammals, yeast, and plants.The Biochemical journal · 2018Review
- OsARD4 encoding an acireductone dioxygenase improves root architecture in rice by promoting development of secondary roots.Scientific reports · 2018Article
- Alteration of cell wall xylan acetylation triggers defense responses that counterbalance the immune deficiencies of plants impaired in the β-subunit of the heterotrimeric G-protein.The Plant journal : for cell and molecular biology · 2017Article
- The Metal Drives the Chemistry: Dual Functions of Acireductone Dioxygenase.Chemical reviews · 2017Review
- Photosynthate Regulation of the Root System Architecture Mediated by the Heterotrimeric G Protein Complex in Arabidopsis.Frontiers in plant science · 2016Article
- Involvement of Iron-Containing Proteins in Genome Integrity in Arabidopsis Thaliana.Genome integrity · 2015Review
- Article
- Changes in expression levels of oxidative stress-related genes in mouse epididymides by neonatal exposure to low-dose decabromodiphenyl ether.Reproductive medicine and biology · 2014Review
- Growth attenuation under saline stress is mediated by the heterotrimeric G protein complex.BMC plant biology · 2014Article
- Heterotrimeric G protein-coupled signaling in plants.Annual review of plant biology · 2014Review
- The Arabidopsis adaptor protein AP-3μ interacts with the G-protein β subunit AGB1 and is involved in abscisic acid regulation of germination and post-germination development.Journal of experimental botany · 2013Article
- Arabidopsis heterotrimeric G protein β subunit, AGB1, regulates brassinosteroid signalling independently of BZR1.Journal of experimental botany · 2013Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Heterotrimeric G protein complexes are conserved from plants to mammals, but the complexity of each system varies. Arabidopsis thaliana contains one Gα, one Gβ (AGB1), and at least three Gγ subunits, allowing it to form three versions of the heterotrimer. This plant model is ideal for genetic studies because mammalian systems contain hundreds of unique heterotrimers. The activation of these complexes promotes interactions between both the Gα subunit and the Gβγ dimer with enzymes and scaffolds to propagate signaling to the cytoplasm. However, although effectors of Gα and Gβ are known in mammals, no Gβ effectors were previously known in plants. Toward identifying AGB1 effectors, we genetically screened for dominant mutations that suppress Gβ-null mutant (agb1-2) phenotypes. We found that overexpression of acireductone dioxygenase 1 (ARD1) suppresses the 2-day-old etiolated phenotype of agb1-2. ARD1 is homologous to prokaryotic and eukaryotic ARD proteins; one function of ARDs is to operate in the methionine salvage pathway. We show here that ARD1 is an active metalloenzyme, and AGB1 and ARD1 both control embryonic hypocotyl length by modulating cell division; they also may contribute to the production of ethylene, a product of the methionine salvage pathway. ARD1 physically interacts with AGB1, and ARD enzymatic activity is stimulated by AGB1 in vitro. The binding interface on AGB1 was deduced using a comparative evolutionary approach and tested using recombinant AGB1 mutants. A possible mechanism for AGB1 activation of ARD1 activity was tested using directed mutations in a loop near the substrate-binding site.
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