ArticleNucleic acids research2011
Diauxic shift-dependent relocalization of decapping activators Dhh1 and Pat1 to polysomal complexes.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Ago1 is required for the regulation of mitochondrial translation under heat stress in Schizosaccharomyces pombe.The Journal of biological chemistry · 2026Article
- Article
- Poxvirus-encoded decapping enzymes promote selective translation of viral mRNAs.PLoS pathogens · 2020Article
- The Interplay between the RNA Decay and Translation Machinery in Eukaryotes.Cold Spring Harbor perspectives in biology · 2018Review
- Translational repression of theRNA (New York, N.Y.) · 2017Article
- Article
- Proteomic Analysis of Dhh1 Complexes Reveals a Role for Hsp40 Chaperone Ydj1 in Yeast P-Body Assembly.G3 (Bethesda, Md.) · 2015Article
- P-body assembly requires DDX6 repression complexes rather than decay or Ataxin2/2L complexes.Molecular biology of the cell · 2015Article
- Not4-dependent translational repression is important for cellular protein homeostasis in yeast.The EMBO journal · 2015Article
- Heat-induced ribosome pausing triggers mRNA co-translational decay in Arabidopsis thaliana.Nucleic acids research · 2015Article
- The DEAD-box helicase Ded1 from yeast is an mRNP cap-associated protein that shuttles between the cytoplasm and nucleus.Nucleic acids research · 2014Article
- An AU-rich instability element in the 3'UTR mediates an increase in mRNA stability in response to expression of a dhh1 ATPase mutant.Translation (Austin, Tex.) · 2014Article
- The DHH1/RCKp54 family of helicases: an ancient family of proteins that promote translational silencing.Biochimica et biophysica acta · 2013Review
- The DEAD-box protein Dhh1 promotes decapping by slowing ribosome movement.PLoS biology · 2012Article
- Interrelations between translation and general mRNA degradation in yeast.Wiley interdisciplinary reviews. RNAReview
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Dhh1 and Pat1 in yeast are mRNA decapping activators/translational repressors thought to play key roles in the transition of mRNAs from translation to degradation. However, little is known about the physical and functional relationships between these proteins and the translation machinery. We describe a previously unknown type of diauxic shift-dependent modulation of the intracellular locations of Dhh1 and Pat1. Like the formation of P bodies, this phenomenon changes the spatial relationship between components involved in translation and mRNA degradation. We report significant spatial separation of Dhh1 and Pat1 from ribosomes in exponentially growing cells. Moreover, biochemical analyses reveal that these proteins are excluded from polysomal complexes in exponentially growing cells, indicating that they may not be associated with active states of the translation machinery. In contrast, under diauxic growth shift conditions, Dhh1 and Pat1 are found to co-localize with polysomal complexes. This work suggests that Dhh1 and Pat1 functions are modulated by a re-localization mechanism that involves eIF4A. Pull-down experiments reveal that the intracellular binding partners of Dhh1 and Pat1 change as cells undergo the diauxic growth shift. This reveals a new dimension to the relationship between translation activity and interactions between mRNA, the translation machinery and decapping activator proteins.
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