ArticleCough (London, England)2011
Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers.
Article in Cough (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Swallowing Pathophysiology in Primary Sarcopenia: A Multimodal Assessment in Older Adults.Dysphagia · 2026Article
- Relationship between age-related changes in the brain detected by plain head computed tomography and cough test results.BMC geriatrics · 2025Observational
- Article
- A New Therapeutic Approach for Dystussia and Atussia in Neurogenic Dysphagia: Effect of Aerosolized Capsaicin on Peak Cough Flow.Dysphagia · 2022Article
- Cough-Inducing Method Using a Tartaric Acid Nebulizer for Patients with Silent Aspiration.Dysphagia · 2022Observational
- The Cough Reflex: The Janus of Respiratory Medicine.Frontiers in physiology · 2021Review
- Methods for assessing cough sensitivity.Journal of thoracic disease · 2020Review
- Cough reflex sensitivity and urge-to-cough deterioration in dementia with Lewy bodies.ERJ open research · 2020Article
- Observational
- Effects of age on effect-site concentration of remifentanil for suppressing anesthetic emergence cough in male patients undergoing laparoscopic cholecystectomy.Clinical interventions in aging · 2018Article
- Dysphagia, dystussia, and aspiration pneumonia in elderly people.Journal of thoracic disease · 2016Article
- Review
- Usefulness of the simplified cough test in evaluating cough reflex sensitivity as a screening test for silent aspiration.Annals of rehabilitation medicine · 2014Article
- Effect of aging on cough and swallowing reflexes: implications for preventing aspiration pneumonia.Lung · 2012Review
- Effect-site concentration of remifentanil for preventing cough during emergence in elderly patients undergoing nasal surgery: a comparison with adult patients.Clinical interventions in agingArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effect of aging on the cognitive aspect of cough has not been studied yet. The purpose of this study is to investigate the aging effect on the perception of urge-to-cough in healthy individuals.
methodsFourteen young, female, healthy never-smokers were recruited via public postings. Twelve elderly female healthy never-smokers were recruited from a nursing home residence. The cough reflex threshold and the urge-to-cough were evaluated by inhalation of citric acid. The cough reflex sensitivities were defined as the lowest concentration of citric acid that elicited two or more coughs (C2) and five or more coughs (C5). The urge-to-cough was evaluated using a modified the Borg scale.
resultsThere was no significant difference in the cough reflex threshold to citric acid between young and elderly subjects. The urge-to-cough scores at the concentration of C2 and C5 were significantly smaller in the elderly than young subjects. The urge-to-cough log-log slope in elderly subjects (0.73 ± 0.71 point · L/g) was significantly gentler than those of young subjects (1.35 ± 0.53 point · L/g, p < 0.01). There were no significant differences in the urge-to-cough threshold estimated between young and elderly subjects.
conclusionsThe cough reflex threshold did not differ between young and elderly subjects whereas cognition of urge-to-cough was significantly decreased in elderly subjects in female never-smokers. Objective monitoring of cough might be important in the elderly people.
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