ArticlePigment cell & melanoma research2011
Constitutive activation of the ETS-1-miR-222 circuitry in metastatic melanoma.
Article in Pigment cell & melanoma research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- MRGBMDAT: a multi-relational graph encoder network with bilinear fusion for miRNA-disease association type prediction.Bioinformatics (Oxford, England) · 2026Article
- Brief research report: ETS-1 blockade increases ICAM-1 expression in activated human retinal endothelial cells.Frontiers in ophthalmology · 2024Article
- Sex and Gender Disparities in Melanoma.Cancers · 2020Review
- Review
- Genomic sites hypersensitive to ultraviolet radiation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Regulation of CEACAM1 Protein Expression by the Transcription Factor ETS-1 in BRAF-Mutant Human Metastatic Melanoma Cells.Neoplasia (New York, N.Y.) · 2018Article
- Sex disparity in cancer: roles of microRNAs and related functional players.Cell death and differentiation · 2018Review
- Abl and Arg mediate cysteine cathepsin secretion to facilitate melanoma invasion and metastasis.Science signaling · 2018Article
- MiR-221, a potential prognostic biomarker for recurrence in papillary thyroid cancer.World journal of surgical oncology · 2017Article
- Matrix metalloproteinase-1 induction by diethyldithiocarbamate is regulated via Akt and ERK/miR222/ETS-1 pathways in hepatic stellate cells.Bioscience reports · 2016Article
- Recent exposure to ultrafine particles in school children alters miR-222 expression in the extracellular fraction of saliva.Environmental health : a global access science source · 2016Article
- AP2α controls the dynamic balance between miR-126&126* and miR-221&222 during melanoma progression.Oncogene · 2016Article
- PC-TraFF: identification of potentially collaborating transcription factors using pointwise mutual information.BMC bioinformatics · 2015Article
- A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme.Oncotarget · 2015Article
- Article
- Interplay Between Metabolism and Oncogenic Process: Role of microRNAs.Translational oncogenomics · 2015Review
- Deregulation of microRNA expression in thyroid neoplasias.Nature reviews. Endocrinology · 2014Review
- The abrogation of the HOXB7/PBX2 complex induces apoptosis in melanoma through the miR-221&222-c-FOS pathway.International journal of cancer · 2013Article
- Review
- miR-222 contributes to sex-dimorphic cardiac eNOS expression via ets-1.Physiological genomics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs-221 and -222 are highly upregulated in several solid tumors, including melanomas. We demonstrate that the proto-oncogene ETS-1, involved in the pathogenesis of cancers of different origin, is a transcriptional regulator of miR-222 by direct binding to its promoter region. Differently from 293FT cells or early stage melanomas, where unphosphorylated ETS-1 represses miR-222 transcription, in metastatic melanoma the constitutively Thr-38 phosphorylated fraction of ETS-1 induces miR-222. Despite its stepwise decreased expression along with melanoma progression, the oncogenic activity of ETS-1 relies on its RAS/RAF/ERK-dependent phosphorylation status more than on its total amount. To close the loop, we demonstrate ETS-1 as a direct target of miR-222, but not miR-221, showing the novel option of their uncoupled functions. In addition, a spatial redistribution of ETS-1 protein from the nucleus to the cytoplasm is also evidenced in advanced melanoma cells. Finally, in vivo studies confirmed the contribution of miR-222 to the increased invasive potential obtained by ETS- silencing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.