ArticleThe Biochemical journal2011
Why does mitochondrial complex I have so many subunits?
Article in The Biochemical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Global conformations ofScience advances · 2025Article
- Mitochondrial DNA Dysfunction in Cardiovascular Diseases: A Novel Therapeutic Target.Antioxidants (Basel, Switzerland) · 2025Review
- The coupling mechanism of mammalian mitochondrial complex I.Nature structural & molecular biology · 2022Article
- An Unexpectedly Complex Mitoribosome in Andalucia godoyi, a Protist with the Most Bacteria-like Mitochondrial Genome.Molecular biology and evolution · 2021Article
- Respiratory chain Complex I of unparalleled divergence in diplonemids.The Journal of biological chemistry · 2018Article
- Cytonuclear integration and co-evolution.Nature reviews. Genetics · 2018Review
- Coenzyme QEssays in biochemistry · 2018Review
- Energy conversion, redox catalysis and generation of reactive oxygen species by respiratory complex I.Biochimica et biophysica acta · 2016Review
- Mitochondrial proteomes of porcine kidney cortex and medulla: foundation for translational proteomics.Clinical and experimental nephrology · 2016Article
- Structure of subcomplex Iβ of mammalian respiratory complex I leads to new supernumerary subunit assignments.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Complete Mitochondrial Complex I Deficiency Induces an Up-Regulation of Respiratory Fluxes That Is Abolished by Traces of Functional Complex I.Plant physiology · 2015Article
- Differential Expression of Genes that Control Respiration Contribute to Thermal Adaptation in Redband Trout (Oncorhynchus mykiss gairdneri).Genome biology and evolution · 2015Article
- Mitochondrial disease associated with complex I (NADH-CoQ oxidoreductase) deficiency.Journal of inherited metabolic disease · 2015Review
- Cystic fibrosis-related oxidative stress and intestinal lipid disorders.Antioxidants & redox signaling · 2015Review
- Essential regions in the membrane domain of bacterial complex I (NDH-1): the machinery for proton translocation.Journal of bioenergetics and biomembranes · 2014Review
- Characterisation of the active/de-active transition of mitochondrial complex I.Biochimica et biophysica acta · 2014Review
- ND3, ND1 and 39kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I.Biochimica et biophysica acta · 2014Article
- Regulation of mitochondrial genome inheritance by autophagy and ubiquitin-proteasome system: implications for health, fitness, and fertility.BioMed research international · 2014Review
- Assembly factors for the membrane arm of human complex I.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Ndufaf5 deficiency in the Dictyostelium model: new roles in autophagy and development.Molecular biology of the cell · 2013Article
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1 author at 1 institution in 1 country.
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Abstract
The prokaryotic and eukaryotic homologues of complex I (proton-pumping NADH:quinone oxidoreductase) perform the same function in energy transduction, but the eukaryotic enzymes are twice as big as their prokaryotic cousins, and comprise three times as many subunits. Fourteen core subunits are conserved in all complexes I, and are sufficient for catalysis - so why are the eukaryotic enzymes embellished by so many supernumerary or accessory subunits? In this issue of the Biochemical Journal, Angerer et al. have provided new evidence to suggest that the supernumerary subunits are important for enzyme stability. This commentary aims to put this suggestion into context.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.