ArticleImmunogenetics2011
Defining the turkey MHC: identification of expressed class I- and class IIB-like genes independent of the MHC-B.
Article in Immunogenetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- A new chromosome-scale duck genome shows a major histocompatibility complex with several expanded multigene families.BMC biology · 2024Article
- Mass Spectrometry Defines Lysophospholipids as Ligands for Chicken MHCY Class I Molecules.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Article
- Major histocompatibility complex genes and locus organization in the Komodo dragon (Varanus komodoensis).Immunogenetics · 2021Article
- Hybrid Versus Autochthonous Turkey Populations: Homozygous Genomic Regions Occurrences Due to Artificial and Natural Selection.Animals : an open access journal from MDPI · 2020Article
- Not all birds have a single dominantly expressed MHC-I gene: Transcription suggests that siskins have many highly expressed MHC-I genes.Scientific reports · 2019Article
- Review
- Expression and phylogenetic analyses reveal paralogous lineages of putatively classical and non-classical MHC-I genes in three sparrow species (Passer).BMC evolutionary biology · 2017Article
- Targeted capture enrichment and sequencing identifies extensive nucleotide variation in the turkey MHC-B.Immunogenetics · 2016Article
- Modulation of the spleen transcriptome in domestic turkey (Meleagris gallopavo) in response to aflatoxin B1 and probiotics.Immunogenetics · 2015Article
- Genetic variation of the major histocompatibility complex (MHC class II B gene) in the threatened Hume's pheasant, Syrmaticus humiae.PloS one · 2015Article
- Comparative cytogenomics of poultry: mapping of single gene and repeat loci in the Japanese quail (Coturnix japonica).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2014Article
- Characteristics of MHC class I genes in house sparrows Passer domesticus as revealed by long cDNA transcripts and amplicon sequencing.Journal of molecular evolution · 2013Article
- Evolutionary history of black grouse major histocompatibility complex class IIB genes revealed through single locus sequence-based genotyping.BMC genetics · 2013Article
- In silico peptide-binding predictions of passerine MHC class I reveal similarities across distantly related species, suggesting convergence on the level of protein function.Immunogenetics · 2013Article
- Characterization of MHC class I in a long-distance migrant shorebird suggests multiple transcribed genes and intergenic recombination.Immunogenetics · 2013Article
- Greater prairie chickens have a compact MHC-B with a single class IA locus.Immunogenetics · 2013Article
- MHC class IIB exon 2 polymorphism in the Grey partridge (Perdix perdix) is shaped by selection, recombination and gene conversion.PloS one · 2013Article
- A comparative physical map reveals the pattern of chromosomal evolution between the turkey (Meleagris gallopavo) and chicken (Gallus gallus) genomes.BMC genomics · 2011Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The MHC of the turkey (Meleagris gallopavo) is divided into two genetically unlinked regions; the MHC-B and MHC-Y. Although previous studies found the turkey MHC-B to be highly similar to that of the chicken, little is known of the gene content and extent of the MHC-Y. This study describes two partially overlapping large-insert BAC clones that genetically and physically map to the turkey MHC chromosome (MGA18) but to a region that assorts independently of MHC-B. Within the sequence assembly, 14 genes were predicted including new class I- and class IIB-like loci. Additional unassembled sequences corresponded to multiple copies of the ribosomal RNA repeat unit (18S-5.8S-28S). Thus, this newly identified MHC region appears to represent a physical boundary of the turkey MHC-Y. High-resolution multi-color fluorescence in situ hybridization studies confirm rearrangement of MGA18 relative to the orthologous chicken chromosome (GGA16) in regard to chromosome architecture, but not gene order. The difference in centromere position between the species is indicative of multiple chromosome rearrangements or alternate events such as neocentromere formation/centromere inactivation in the evolution of the MHC chromosome. Comparative sequencing of commercial turkeys (six amplicons totaling 7.6 kb) identified 68 single nucleotide variants defining nine MHC-Y haplotypes. Sequences of the new class I- and class IIB-like genes are most similar to MHC-Y genes in the chicken. All three loci are expressed in the spleen. Differential transcription of the MHC-Y class IIB-like loci was evident as one class IIB-like locus was only expressed in some individuals.
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