ArticleEcotoxicology (London, England)2011
Arsenic-induced changes in morphological, physiological, and biochemical attributes and artemisinin biosynthesis in Artemisia annua, an antimalarial plant.
Article in Ecotoxicology (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 64 citations in OpenAlex.
- Exogenous kinetin mitigates arsenic-induced oxidative stress by regulating ROS homeostasis and antioxidant defense in Ocimum basilicum L.Plant cell reports · 2026Article
- Metal uptake in sweet peppers cultivated in soils contaminated by artisanal gold mining: implications for food safety.Environmental geochemistry and health · 2026Article
- The Good, the Bad, and the Epigenetic: Stress-Induced Metabolite Regulation and Transgenerational Effects.Epigenomes · 2025Review
- Growth, Biochemical Traits, Antioxidant Enzymes, and Essential Oils of Four Aromatic and Medicinal Plants Cultivated in Phosphate-Mine Residues.Plants (Basel, Switzerland) · 2024Article
- Ultraviolet-B and Heavy Metal-Induced Regulation of Secondary Metabolites in Medicinal Plants: A Review.Metabolites · 2023Review
- Oligochitosan fortifies antioxidative and photosynthetic metabolism and enhances secondary metabolite accumulation in arsenic-stressed peppermint.Frontiers in plant science · 2022Article
- Vicia villosa Roth: a cover crop to phytoremediate arsenic polluted environments.Environmental science and pollution research international · 2021Article
- Carrageenan oligomers and salicylic acid act in tandem to escalate artemisinin production by suppressing arsenic uptake and oxidative stress in Artemisia annua (sweet wormwood) cultivated in high arsenic soil.Environmental science and pollution research international · 2021Article
- Heterologous expression of cyanobacterialPlant biotechnology reports · 2021Article
- Oligomers of carrageenan regulate functional activities and artemisinin production in Artemisia annua L. exposed to arsenic stress.Protoplasma · 2020Article
- Article
- Updates on artemisinin: an insight to mode of actions and strategies for enhanced global production.Protoplasma · 2016Review
- Selenium ameliorates arsenic induced oxidative stress through modulation of antioxidant enzymes and thiols in rice (Oryza sativa L.).Ecotoxicology (London, England) · 2014Article
- Enhanced Photosynthesis and Carbon Metabolism Favor Arsenic Tolerance in Artemisia annua, a Medicinal Plant as Revealed by Homology-Based Proteomics.International journal of proteomics · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Present study is the first to explore physiological, biochemical and molecular changes in the medicinal plant Artemisia annua under arsenic (As) stress. A. annua grown hydroponically in a nutrient solution was spiked with increasing doses of As (0, 1,500, 3,000 and 4,500 μg l(-1)) for 7 days. Plants accumulated As in a dose dependent manner with bioconcentration factor 13.4 and translocation factor 0.97. While a similar trend of As accumulation was observed under soil culture experiments, the transfer factor went up to 2.1, depicting high efficiency of As translocation from roots to shoots by A. annua. Plants raised in 0-3,000 μg l(-1) As containing nutrient solution registered increase in root length, biomass, and carotenoid contents without any visual toxicity symptoms. A dose dependent increase in the activities of enzymes such as superoxide dismutase, ascorbate peroxidase, glutathione reductase and guaiacol peroxidase followed by a gradual decline at higher concentrations suggested their role in alleviating oxidative stress. Significant increase in the levels of thiols, GSH, and pcs gene transcript up to 3,000 μg l(-1) As attested their roles in As detoxification. Enhanced artemisinin production (an antimalarial compound) under As stress and upregulation of the transcripts (measured by RT-PCR) of the genes HMGR, FDS, ADS, and CYP71AV1 involved in artemisinin biosynthesis reaffirmed induction of artemisinin biosynthesis in A. annua under As stress. The results of the present study vividly suggested that A. annua has considerable As tolerance, and thus can be successfully cultivated in As contaminated fields.
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