ArticleEuropean biophysics journal : EBJ2011
Zinc modulates copper coordination mode in prion protein octa-repeat subdomains.
Article in European biophysics journal : EBJ, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 38 citations in OpenAlex.
- Aggregates Sealed by Ions.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Molecular Features of the ZnBiophysical journal · 2019Article
- Cu(II)-Zn(II) Cross-Modulation in Amyloid-Beta Peptide Binding: An X-ray Absorption Spectroscopy Study.The journal of physical chemistry. B · 2015Article
- Copper-zinc cross-modulation in prion protein binding.European biophysics journal : EBJ · 2014Article
- ESEEM analysis of multi-histidine Cu(II)-coordination in model complexes, peptides, and amyloid-β.The journal of physical chemistry. B · 2014Article
- Lipid rafts: linking prion protein to zinc transport and amyloid-β toxicity in Alzheimer's disease.Frontiers in cell and developmental biology · 2014Article
- The tachykinin peptide neurokinin B binds copper forming an unusual [CuII(NKB)2] complex and inhibits copper uptake into 1321N1 astrocytoma cells.ACS chemical neuroscience · 2013Article
- Zn(II) ions substantially perturb Cu(II) ion coordination in amyloid-β at physiological pH.The journal of physical chemistry. B · 2013Article
- Article
- Prion protein facilitates uptake of zinc into neuronal cells.Nature communications · 2012Article
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
In this work we present and analyse XAS measurements carried out on various portions of Prion-protein tetra-octa-repeat peptides in complexes with Cu(II) ions, both in the presence and in the absence of Zn(II). Because of the ability of the XAS technique to provide detailed local structural information, we are able to demonstrate that Zn acts by directly interacting with the peptide, in this way competing with Cu for binding with histidine. This finding suggests that metal binding competition can be important in the more general context of metal homeostasis.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.