ReviewArchives of toxicology2012
Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances.
Review in Archives of toxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
183 citing papers in PubMed, 3 syntheses or guidelines pooled it, 592 citations in OpenAlex.
- Repellent effects of insecticides against Aedes aegypti: a systematic review.Parasites & vectors · 2025Pooled it
- Systematic review of clinical manifestations, management and outcome following accidental ingestion of liquid mosquito repellent vaporiser in children.BMJ paediatrics open · 2024Pooled it
- Quantifying synergistic interactions: a meta-analysis of joint effects of chemical and parasitic stressors.Scientific reports · 2023Pooled it
- Mutations M918T, M918L, and L1014F impair pyrethroid binding and alter gating of the Megalurothrips usitatus sodium channel.Pest management science · 2026Article
- First Report on Field-Evolved Resistance to Lambda-Cyhalothrin in Rice Leaf Folder (Cnaphalocrocis medinalis Guenee) Populations in Kerala, India: Implications and Concerns of Its Environmental Impact.Environmental toxicology · 2026Article
- Resistance to pyrethroids in Aedes aegypti: Insights into transcriptomic response to different insecticide concentrations.PLoS neglected tropical diseases · 2026Article
- Metabolomic Changes Underpinning Permethrin Resistance in theACS measurement science au · 2026Article
- Genotypic detection of synthetic pyrethroid and organophosphate resistance-associated mutations in Rhipicephalus (Boophilus) microplus infesting ruminants across three agro-ecological zones in Pakistan.Experimental & applied acarology · 2026Article
- Effects of Pesticides Commonly Used in Avocado onInsects · 2026Article
- Evaluation of Insecticide Resistance inInsects · 2026Article
- Morphological and toxicological effects of a deltamethrin-based insecticide on aquatic insect larvae: Grumichella boraceia (Trichoptera) as a bioindicator of pyrethroid contamination.Ecotoxicology (London, England) · 2026Article
- Callosal glia, GABAergic interneurons, and apoptotic profiles in the brains of cypermethrin-exposed male and female rats.BMC research notes · 2026Article
- Behavioral disruption in honey bees (Apis mellifera) exposed to isolated and combined insecticides.Ecotoxicology (London, England) · 2026Article
- Review
- Article
- Knockdown resistance (kdr) mutations in the Japanese encephalitis virus vector Culex tritaeniorhynchus from the Republic of Korea.Tropical medicine and health · 2026Article
- Metabolic resistance of the tiger mosquito to pyrethroid insecticides in La Réunion Island likely results from local adaptation.Genome biology and evolution · 2026Article
- Genetic Surveillance Reveals Differential Evolutionary Dynamic of Anopheles gambiae Under Contrasting Insecticidal Tools Used in Malaria Control.Molecular ecology · 2026Article
- Research progress on functional carbon quantum dots fluorescent probes for detecting pesticide residues in food.Mikrochimica acta · 2026Review
- Development of Advanced Nanobiosensors and a Portable Monitoring System for Pesticide Detection at the Point of Need.Biosensors · 2026Article
123 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Synthetic pyrethroid insecticides were introduced into widespread use for the control of insect pests and disease vectors more than three decades ago. In addition to their value in controlling agricultural pests, pyrethroids are at the forefront of efforts to combat malaria and other mosquito-borne diseases and are also common ingredients of household insecticide and companion animal ectoparasite control products. The abundance and variety of pyrethroid uses contribute to the risk of exposure and adverse effects in the general population. The insecticidal actions of pyrethroids depend on their ability to bind to and disrupt voltage-gated sodium channels of insect nerves. Sodium channels are also important targets for the neurotoxic effects of pyrethroids in mammals but other targets, particularly voltage-gated calcium and chloride channels, have been implicated as alternative or secondary sites of action for a subset of pyrethroids. This review summarizes information published during the past decade on the action of pyrethroids on voltage-gated sodium channels as well as on voltage-gated calcium and chloride channels and provides a critical re-evaluation of the role of these three targets in pyrethroid neurotoxicity based on this information.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.