Evidence map›Paper›PMID 21710246›Full record

SynthesisMolecular biology reports2012

Association between CYP1A1 polymorphism and colorectal cancer risk: a meta-analysis.

Yuan Zheng, Jing-Jun Wang, Liang Sun, Hong-Lei Li

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 14 pooled it
7.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 14 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  5. CYP1A1 polymorphism interactions with smoking status in oral cancer risk: evidence from epidemiological studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
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  9. Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated meta-analysis including 1,515 cases and 2,233 controls.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012
    Pooled it
  10. Quantitative assessment of the associations between CYP1A1 polymorphisms and gastric cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012
    Pooled it
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  15. Journal of clinical medicine · 2026
    Article
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  18. The Relationship ofJournal of clinical medicine · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Yuan ZhengDepartment of Center for Disease Control and Prevention of Shaanxi Province, 3Jiandong Road, 710054, Shaanxi, Xi'an, People's Republic of China.
Jing-Jun Wang
Liang Sun
Hong-Lei Li
Xian Center for Disease Control and Prevention · CNCenters for Disease Control and Prevention · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer is one of the most common forms of cancer and is the third leading cause of cancer-related death worldwide. Published data on the association between CYP1A1 (MspI and Ile ( 462 ) Val) polymorphisms and colorectal cancer risk are inconclusive. To address these issues, we carried out a meta-analysis of available case-control study. Online electronic searches of PubMed were performed. We identified 17 studies (6,673 colorectal cancer patients and 8,102 control subjects) that examined the association between CYP1A1 (MspI and Ile ( 462 ) Val) polymorphisms and risk of colorectal cancer. For CYP1A1 MspI polymorphism, we performed a meta-analysis from 13 studies including 5,468 cases and 6,492 controls. Overall, there was no statistically significant association between CYP1A1 MspI polymorphism and colorectal cancer susceptibility. In the subgroup analyses based on ethnicities, no statistically significant associations were observed in all genetic models. With respect to CYP1A1 Ile ( 462 ) Val polymorphism, a total of 14 studies including 6,654 cases and 7,859 controls were involved in this meta-analysis. The CYP1A1 Ile ( 462 ) Val polymorphism was associated with risk of colorectal cancer. Ethnic subgroup analyses revealed that significant associations were found in Asians and Caucasians. In summary, this meta-analysis suggests that CYP1A1 Ile ( 462 ) Val polymorphism was a low-penetrance susceptibility gene in colorectal cancer development. On the contrary, CYP1A1 MspI polymorphism does not seem capable of modifying colorectal cancer risk.

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseasePolymorphism, GeneticAllelesColorectal NeoplasmsCytochrome P-450 CYP1A1Databases, GeneticGene FrequencyGenes, DominantGenes, RecessiveHumansModels, GeneticPolymorphism, Single NucleotidePublication BiasRisk FactorsCYP1A1 protein, humanCytochrome P-450 CYP1A1

Identifiers

PMID21710246
OpenAlexW2094121022

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.