Trial reportPsychopharmacology2011
Stress- and cue-elicited craving and reactivity in marijuana-dependent individuals.
Trial report in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- A meta-analytic review of the effectiveness of mood inductions in eliciting emotion-based behavioral risk-taking and craving in the laboratory.Emotion (Washington, D.C.) · 2023Pooled it
- The Impact of Co-occurring Post-traumatic Stress Disorder and Substance Use Disorders on Craving: A Systematic Review of the Literature.Frontiers in psychiatry · 2021Pooled it
- A preliminary randomized controlled trial of repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex in treatment seeking participants with cannabis use disorder.Drug and alcohol dependence · 2024Trial
- Cue-induced cocaine craving enhances psychosocial stress and vice versa in chronic cocaine users.Translational psychiatry · 2022Trial
- Laboratory-induced stress and craving predict opioid use during follow-up among individuals with prescription opioid use disorder.Drug and alcohol dependence · 2021Trial
- Impact of a computerized intervention for high distress intolerance on cannabis use outcomes: A randomized controlled trial.Journal of substance abuse treatment · 2021Trial
- The effect of oxytocin, gender, and ovarian hormones on stress reactivity in individuals with cocaine use disorder.Psychopharmacology · 2020Trial
- Testing the role of the posterior cingulate cortex in processing salient stimuli in cannabis users: an rTMS study.The European journal of neuroscience · 2019Trial
- Approach bias modification for cannabis use disorder: A proof-of-principle study.Journal of substance abuse treatment · 2018Trial
- Repetitive transcranial magnetic stimulation (rTMS) administration to heavy cannabis users.The American journal of drug and alcohol abuse · 2018Trial
- Impact of acute guanfacine administration on stress and cue reactivity in cocaine-dependent individuals.The American journal of drug and alcohol abuse · 2015Trial
- Sex differences in stress responding in a randomized, placebo-controlled clinical trial of progesterone in cannabis use disorder.Psychopharmacology · 2026Article
- The Neurocircuitry of Cannabis Cue Reactivity in Cannabis Use Disorder: A Functional Neuroimaging Study.Biological psychiatry global open science · 2026Article
- Artificial Intelligence Approximates Human Affect Ratings of Cannabis Images.medRxiv : the preprint server for health sciences · 2025Article
- A Secondary Analysis Suggests That Repetitive Transcranial Magnetic Stimulation Applied to the Left Dorsolateral Prefrontal Cortex Reduces Cue-Induced-Craving in Treatment Seeking Participants with Cannabis Use Disorder.medRxiv : the preprint server for health sciences · 2025Article
- Biological sex and hormonal contraceptive associations with drug cue reactivity in cannabis use disorder.Journal of psychiatric research · 2024Article
- Sex and drug differences in stress, craving and cortisol response to the trier social stress task.Psychopharmacology · 2022Article
- Emotional distress and pain catastrophizing predict cue-elicited opioid craving among chronic pain patients on long-term opioid therapy.Drug and alcohol dependence · 2022Article
- Article
- A review of the effects of acute and chronic cannabinoid exposure on the stress response.Frontiers in neuroendocrinology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleCue-elicited craving and stress responses have been identified as predictors of relapse in drug dependence, but little research exists on the contribution of these factors to marijuana use specifically.
objectivesThe aims of the present study were to evaluate (1) responses to a psychological stressor, (2) responses to marijuana-related cues, and (3) if an exposure to a psychological stressor augmented craving subsequently elicited by marijuana-related cue exposure in marijuana-dependent individuals.
methodsSubjective (craving, stress), neuroendocrine (adrenocorticotropic hormone (ACTH), cortisol), and physiologic responses to the presentation of neutral and marijuana cues were assessed after randomization to a stress (Trier Social Stress Task (TSST)) or non-stress control condition in marijuana-dependent individuals. Outcome measures were assessed at baseline, post-stressor/pre-neutral cue, post-neutral cue, and post-marijuana cue.
resultsEighty-seven participants completed procedures (stress group, n = 45; non-stress group, n = 42). The stress group had a significant increase over the non-stress group in stress rating (p < 0.001), craving (p = 0.028), cortisol (p < 0.001), and ACTH (p < 0.001) after the completion of the TSST. An increased craving response for all participants was seen following the presentation of the marijuana cues (p = 0.005). Following the TSST or non-stress condition, the non-stress group had an increase in craving to marijuana cues as compared to neutral cues (p = 0.002); an increase in craving was not observed in the stress group (p = 0.404).
conclusionsMarijuana cue exposure and a social stressor increased craving in marijuana-dependent individuals. Completion of the TSST did not increase craving response to subsequent marijuana cue exposure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.