ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2012
High APOE epsilon 4 allele frequencies associated with Alzheimer disease in a Tunisian population.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 43 citations in OpenAlex.
- Clinical and neuropsychological profile of Alzheimer's disease in Tunisia and the impact ofFrontiers in genetics · 2026Article
- Genetics and environmental determinants of Alzheimer's disease and related dementias in older Africans: a narrative review.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025Review
- Missing apolipoprotein E ε4 allele associated with nonamnestic Alzheimer's disease in a Tunisian population.Journal of genetics · 2022Article
- Article
- APOE and Alzheimer's Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer's Pathogenesis.Molecular neurobiology · 2019Review
- Apolipoprotein E as a Therapeutic Target in Alzheimer's Disease: A Review of Basic Research and Clinical Evidence.CNS drugs · 2016Review
- Neurogenomics in Africa: Perspectives, progress, possibilities and priorities.Journal of the neurological sciences · 2016Review
- Association between ACE polymorphism, cognitive phenotype and APOE E4 allele in a Tunisian population with Alzheimer disease.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- Decreased expression of the APOA1-APOC3-APOA4 gene cluster is associated with risk of Alzheimer's disease.Drug design, development and therapy · 2015Article
- Serum calreticulin is a negative biomarker in patients with Alzheimer's disease.International journal of molecular sciences · 2014Article
- Exercise, APOE genotype, and the evolution of the human lifespan.Trends in neurosciences · 2014Review
- Association between Alzheimer disease and the -491T allele of regulatory region polymorphism of Apolipoprotein E in a Tunisian population.Neurochemical research · 2014Article
- No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a Tunisian population.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- Protective effect of the APOE-e3 allele in Alzheimer's disease.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2012Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The goal of the study was to examine the Apolipoprotein E (APOE) genotypes in a Tunisian sample of patients with Alzheimer disease (AD) and normal controls, and to compare the results with the findings from the literature. A hospital-based case-control study of two groups (58 patients with AD, 71 controls) was conducted. Patients received a detailed clinical history, neurological examination, neuropsychological testing and brain imaging. A neurological examination and the Arabic version of the Mini-Mental State Examination were made for controls. Genotyping was performed using the PCR restriction fragment length polymorphism (PCR-RFLP) method. There were no statistical differences in age (p = 0.05) and gender (p = 0.046) between the two groups. The APOE ε4/4 genotype was over represented in the AD group in comparison with the controls (13.3 vs. 2.8%). A significant increased risk of AD among APOE ε4 allele carriers was observed. The odds ratio for the association of AD patients with homozygous and heterozygous ε4 allele was, respectively, 5.40 (1.35-21.48) and 2.90 (1.27-6.62). Our results in addition to previously published genetic studies suggest that AD disease is multifactor in origin. Ethnicity, genetic and environmental factors contribute to AD risk in different ethnic groups.
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