ArticleLab on a chip2011
Integrated microfluidic array plate (iMAP) for cellular and molecular analysis.
Article in Lab on a chip, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Single-cell omics: experimental workflow, data analyses and applications.Science China. Life sciences · 2025Review
- High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology.Chemical reviews · 2021Review
- Fusing MEMS technology with lab-on-chip: nanoliter-scale silicon microcavity arrays for digital DNA quantification and multiplex testing.Microsystems & nanoengineering · 2020Article
- An in vitro pressure model towards studying the response of primary retinal ganglion cells to elevated hydrostatic pressures.Scientific reports · 2019Article
- Pumpless platform for high-throughput dynamic multicellular culture and chemosensitivity evaluation.Lab on a chip · 2019Article
- Image decoding of photonic crystal beads array in the microfluidic chip for multiplex assays.Scientific reports · 2014Article
- Toward integrated molecular diagnostic system (i MDx): principles and applications.IEEE transactions on bio-medical engineering · 2014Review
- Smart-phone based computational microscopy using multi-frame contact imaging on a fiber-optic array.Lab on a chip · 2013Article
- Microdevice integrating innate and adaptive immune responses associated with antigen presentation by dendritic cells.RSC advances · 2013Article
- Micro total analysis systems: fundamental advances and applications in the laboratory, clinic, and field.Analytical chemistry · 2013Review
- Nanopore-induced spontaneous concentration for optofluidic sensing and particle assembly.Analytical chemistry · 2013Article
- Optical imaging techniques for point-of-care diagnostics.Lab on a chip · 2013Review
- Label-free isolation of circulating tumor cells in microfluidic devices: Current research and perspectives.Biomicrofluidics · 2013Article
- An integrated microfluidic platform for in situ cellular cytokine secretion immunophenotyping.Lab on a chip · 2012Article
- Optofluidic detection for cellular phenotyping.Lab on a chip · 2012Review
- On-chip open microfluidic devices for chemotaxis studies.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2012Article
- Gravity-oriented microfluidic device for uniform and massive cell spheroid formation.Biomicrofluidics · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Just as the Petri dish has been invaluable to the evolution of biomedical science in the last 100 years, microfluidic cell assay platforms have the potential to change significantly the way modern biology and clinical science are performed. However, an evolutionary process of creating an efficient microfluidic array for many different bioassays is necessary. Specifically for a complete view of a cell response it is essential to incorporate cytotoxic, protein and gene analysis on a single system. Here we present a novel cellular and molecular analysis platform, which allows access to gene expression, protein immunoassay, and cytotoxicity information in parallel. It is realized by an integrated microfluidic array plate (iMAP). The iMAP enables sample processing of cells, perfusion based cell culture, effective perturbation of biologic molecules or drugs, and simultaneous, real-time optical analysis for different bioassays. The key features of the iMAP design are the interface of on-board gravity driven flow, the open access input fluid exchange and the highly efficient sedimentation based cell capture mechanism (∼100% capture rates). The operation of the device is straightforward (tube and pump free) and capable of handling dilute samples (5-cells per experiment), low reagent volumes (50 nL per reaction), and performing single cell protein and gene expression measurements. We believe that the unique low cell number and triple analysis capabilities of the iMAP platform can enable novel dynamic studies of scarce cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.