Evidence map›Paper›PMID 21709818›Full record

ArticleFuture neurology2011

Fetal neurosurgery: current state of the art.

Payam Saadai, Timothy Runyon, Diana L Farmer

Abstract read
In one paragraph

Article in Future neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Primary Intracranial High Grade Congenital Glial Lesions (PIHGCL): A systematic review of case reports from 1985 to 2025.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Pooled it
  2. Article
  3. Fetal ventriculomegaly: Diagnosis, treatment, and future directions.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Payam SaadaiFetal Treatment Center, UCSF Benioff Children's Hospital, 513 Parnassus Ave, HSW-1601, Box 0570, San Francisco, CA 94143-0570, USA.
Timothy Runyon
Diana L Farmer

Funding

MULTICENTER TRIAL OF FETAL MYELOMENINGOCELE REPAIRU10HD041669 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FARMER, DIANA LEE · 2002 to 2010
$5.5M
NICHD NIH HHS U10 HD041669
6 · The paper itself

Abstract

Congenital CNS abnormalities have been targets for prenatal intervention since the founding of fetal surgery 30 years ago, but with historically variable results. Open fetal neurosurgery for myelomenigocele has demonstrated the most promising results of any CNS malformation. Improvements in the understanding of congenital diseases and in fetal surgical techniques have reopened the door to applying fetal surgery to other congenital CNS abnormalities. Advances in gene therapy, bioengineering and neonatal neuroprotection will aid in the future expansion of fetal neurosurgery to other CNS disorders.

Identifiers

PMID21709818
PMCPMC3119808

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.