ArticleAdvanced functional materials2010
A Generalized System for Photo-Responsive Membrane Rupture in Polymersomes.
Article in Advanced functional materials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
- Targeting drug delivery with light: A highly focused approach.Advanced drug delivery reviews · 2021Review
- Hybrid lipopolymer vesicle drug delivery and release systems.Journal of biomedical research · 2021Article
- Polymersome Poration and Rupture Mediated by Plasmonic Nanoparticles in Response to Single-Pulse Irradiation.Polymers · 2020Article
- Diblock copolymers enhance folding of a mechanosensitive membrane protein during cell-free expression.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Engineering Polymersomes for Diagnostics and Therapy.Advanced healthcare materials · 2018Review
- Ruthenium-Crosslinked Hydrogels with Rapid, Visible-Light Degradation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Droplet-based microfluidics for artificial cell generation: a brief review.Interface focus · 2016Review
- Enzymatically triggered rupture of polymersomes.Soft matter · 2016Article
- Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations.Nature protocols · 2015Article
- Caging metal ions with visible light-responsive nanopolymersomes.Langmuir : the ACS journal of surfaces and colloids · 2015Article
- Multifunctional polymersomes for cytosolic delivery of gemcitabine and doxorubicin to cancer cells.Biomaterials · 2014Article
- Sensing membrane stress with near IR-emissive porphyrins.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Engineering Polymersome Protocells.The journal of physical chemistry letters · 2011Article
- Recent trends in the tuning of polymersomes' membrane properties.The European physical journal. E, Soft matter · 2011Review
- Biodegradable Polymersomes for the Delivery of Gemcitabine to Panc-1 Cells.Journal of pharmaceuticsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Polymersomes are vesicles whose membranes are comprised of self-assembled block co-polymers. We recently showed that co-encapsulating conjugated multi-porphyrin dyes in a polymersome membrane with ferritin protein in the aqueous lumen confers photo-lability to the polymersome. In the present study, we illustrate that the photo-lability can be extended to vesicles containing dextran, an inert and inexpensive polysaccharide, as the luminal solute. Here we explore how structural features of the polymersome/porphyrin/dextran composite affect its photo-response. Increasing dextran molecular weight, decreasing block copolymer molecular weight, and altering fluorophore-membrane interactions results in increasing the photo-responsiveness of the polymersomes. Amphiphilic interactions of the luminal encapsulant with the membrane coupled with localized heat production in the hydrophobic bilayer likely cause differential thermal expansion in the membrane and the subsequent membrane rupture. This study suggests a general approach to impart photo-responsiveness to any biomimetic vesicle system without chemical modification, as well as a simple, bio-inert method for constructing photo-sensitive carriers for controlled release of encapsulants.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.