ArticleMedical science monitor : international medical journal of experimental and clinical research2011
Phage therapy of Cronobacter-induced urinary tract infection in mice.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Cocktail of genetically diverse lytic phages reduces uropathogenic Escherichia coli colonization in mouse urinary tract.Scientific reports · 2026Article
- A Novel Therapeutic Approach: Phage andScientifica · 2026Article
- The high efficiency protective effectiveness of a newly isolated myoviruses bacteriophage vB_AceP_PAc in protecting mice from Aeromonas caviae infection in mice.BMC microbiology · 2025Article
- Review
- Bacteriophage P2-71: a promising therapeutic against multidrug-resistantFrontiers in veterinary science · 2024Article
- Phage Therapy in the Management of Urinary Tract Infections: A Comprehensive Systematic Review.PHAGE (New Rochelle, N.Y.) · 2023Article
- Bacteriophages as Potential Clinical Immune Modulators.Microorganisms · 2023Review
- Phage therapy: a revolutionary shift in the management of bacterial infections, pioneering new horizons in clinical practice, and reimagining the arsenal against microbial pathogens.Frontiers in medicine · 2023Review
- Bacteriophages as an Alternative Method for Control of Zoonotic and Foodborne Pathogens.Viruses · 2021Review
- A Novel Phage Cocktail Therapy of the Urinary Tract Infection in a Mouse Model.Archives of Razi Institute · 2021Article
- Interactions of Bacteriophages with Animal and Human Organisms-Safety Issues in the Light of Phage Therapy.International journal of molecular sciences · 2021Review
- Review
- Bacteriophage therapy for inhibition of multi drug-resistant uropathogenic bacteria: a narrative review.Annals of clinical microbiology and antimicrobials · 2021Review
- The Role of Antibiotic ResistantAntibiotics (Basel, Switzerland) · 2021Review
- Bacteriophage as an Alternative to Antibiotics Promotes Growth Performance by Regulating Intestinal Inflammation, Intestinal Barrier Function and Gut Microbiota in Weaned Piglets.Frontiers in veterinary science · 2021Article
- Phage Prevalence in the Human Urinary Tract-Current Knowledge and Therapeutic Implications.Microorganisms · 2020Review
- Biological challenges of phage therapy and proposed solutions: a literature review.Expert review of anti-infective therapy · 2019Review
- Phage therapy administered noninvasively could be effective in thin tubes subject to episodic flow despite washout: a simulation study.Physical biology · 2019Article
- A Bipartite Network Module-Based Project to Predict Pathogen-Host Association.Frontiers in genetics · 2019Article
- Semi-Solid and Solid Dosage Forms for the Delivery of Phage Therapy to Epithelia.Pharmaceuticals (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCronobacter spp. is an opportunistic pathogen causing rare but dangerous cases of meningitis, sepsis and urinary tract infection. Phage therapy overcomes antibiotic resistance and represents an alternative approach to standard antimicrobial treatment. There are no published studies on the use of phages against Cronobacter spp. in vivo. The aim of our study was to prove the effects of isolated Cronobacter-specific phages on renal colonization in a model of urinary tract infection in mice. MATERIAL/
methodsUrinary tract infection was induced by transurethral application of Cronobacter turicensis (1011 CFU/ml). Simultaneously, isolated Cronobacter-specific phages were administered intraperitoneally (1011 PFU/ml). After 24 hours, kidneys and bladder were collected and used for cultivation and analysis of gene expression and oxidative stress markers.
resultsPhage therapy reduced the number of Cronobacter colonies in the kidney by 70%. Higher levels of malondialdehyde were reduced by phage therapy without affecting the antioxidant status. The expression of pro-inflammatory cytokines tumor necrosis factor-alpha and monocyte chemoattractant protein-1 increased by the infection and was attenuated by phage therapy.
conclusionsPhage therapy proved effective in the prevention of ascending renal infection in a murine model of urinary tract infection. Long-term effects and safety of the treatment are currently unknown. Further studies should test phage therapy in other Cronobacter infection models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.