ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2011
Homocysteine and cognitive function in very elderly nondemented subjects.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Effect of Maternal Vitamin B12 Supplementation on Cognitive Outcomes in South Indian Children: A Randomized Controlled Clinical Trial.Maternal and child health journal · 2019Trial
- Effects of maternal vitamin B12 supplementation on early infant neurocognitive outcomes: a randomized controlled clinical trial.Maternal & child nutrition · 2017Trial
- XGBoost models based on non imaging features for the prediction of mild cognitive impairment in older adults.Scientific reports · 2025Article
- Hyperhomocysteinemia and its effect on ageing and language functions - HEAL study.Scientific reports · 2024Article
- Stability in BMI over time is associated with a better cognitive trajectory in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Review
- Combined homocysteine and apoE rs429358 and rs7412 polymorphism in association with serum lipid levels and cognition in Chinese community-dwelling older adults.BMC psychiatry · 2022Article
- Prevention of dementia presents a potentially critical platform for improvement of long-term public health.Dialogues in clinical neuroscience · 2019Review
- Functional and/or structural brain changes in response to resistance exercises and resistance training lead to cognitive improvements - a systematic review.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2019Article
- Helicobacter pylori moderates the association between 5-MTHF concentration and cognitive function in older adults.PloS one · 2018Article
- The specific impact of uremic toxins upon cognitive domains: a review.Jornal brasileiro de nefrologiaReview
- Serum Vitamin B12 and thyroid hormone levels in Saudi patients with multiple sclerosis.Journal of family & community medicineArticle
- Correlation of arterial blood pressure and compliance with left ventricular structure and function in the very elderly.Journal of the American Society of Hypertension : JASHArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectivesTo examine the association of homocysteine with cognitive functioning in very elderly community-dwelling individuals (80 years or older).
methodsTwo hundred twenty-eight nondemented community-dwelling individuals were assessed with a broad neuropsychological battery. Bloods were drawn to measure homocysteine, serum vitamin B12, and folate levels and APOE genotype.
resultsHigher homocysteine levels were associated with poorer executive-language functioning scores (r = -0.311). The association persisted when serum B12 and folate levels were controlled for (r = -0.308). Homocysteine levels were not associated with memory score (r = 0.120).
conclusionsIn very elderly, nondemented community dwellers, high homocysteine levels are associated with poorer executive-language functioning but not with memory. This possible differential effect of homocysteine on cognitive functions suggests that it may affect only specific brain regions or mechanisms underlying healthy executive functioning.
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