ArticleProceedings of the National Academy of Sciences of the United States of America2011
Sugar-regulated cation channel formed by an insect gustatory receptor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers.
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Who cites it
135 citing papers in PubMed, 297 citations in OpenAlex.
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- Antennal transcriptome analysis and expression profiling of odorant binding proteins and odorant receptors in the teak defoliator, Hyblaea puera (Lepidoptera: Hyblaeidae).BMC genomics · 2026Article
- Early hexapod genomes reveal the deep origin of insect gustatory and odorant receptors.Nature communications · 2026Article
- Expanding the sensory horizon: chemosensory receptors beyond traditional olfactory and taste organs in insects.Science China. Life sciences · 2026Review
- The impact of sugar diet on humidity preference, survival, and host landing in mosquitoes.Journal of medical entomology · 2025Article
- Transcriptome sequencing of Antheraea pernyi antennae for identification of olfactory-related genes.BMC genomics · 2025Article
- Sugar-sensing swodkoreceptors and swodkocrine signaling.Animal models and experimental medicine · 2025Article
- A structural perspective on insect gustatory receptors.Chemical senses · 2025Review
- Opponent coding mechanisms in Drosophila taste neurons.Chemical senses · 2025Review
- Harnessing Insect Chemosensory and Mechanosensory Receptors Involved in Feeding for Precision Pest Management.Life (Basel, Switzerland) · 2025Review
- Molecular Functions and Physiological Roles of Gustatory Receptors of the SilkwormInternational journal of molecular sciences · 2024Review
- Genome-wide analysis of gustatory receptor genes and identification of the fructose gustatory receptor inHeliyon · 2024Article
- The larva and adult ofeLife · 2024Article
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- Structural basis of ligand specificity and channel activation in an insect gustatory receptor.Cell reports · 2024Article
- Molecular and Functional Characterization of Three General Odorant-Binding Protein 2 Genes inInternational journal of molecular sciences · 2024Article
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- Identification of candidate chemosensory genes in the antennal transcriptome of Monolepta signata.PloS one · 2024Article
- Identification of candidate chemosensory genes inFrontiers in physiology · 2024Article
75 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insects sense the taste of foods and toxic compounds in their environment through the gustatory system. Genetic studies using fruit flies have suggested that putative seven-transmembrane gustatory receptors (Grs) expressed in gustatory sensory neurons are required for responses to specific tastants. We reconstituted sugar responses of Bombyx mori Gr-9 (BmGr-9), a silkworm Gr, in two heterologous expression systems. Xenopus oocytes or HEK293T cells expressing BmGr-9 selectively responded to D-fructose with an influx of extracellular Ca(2+) and a nonselective cation current conductance in a G protein-independent manner. Outside-out patch-clamp recording of BmGr-9-expressing cell membranes provides evidence supporting the hypothesis that BmGr-9 constitutes a ligand-gated ion channel. The fructose-activated current associated with BmGr-9 was suppressed by other hexoses, including glucose and sorbose. The activation and inhibition of insect Gr ion channels may be the molecular basis for the decoding system that discriminates subtle differences in sweet taste. Finally, Drosophila melanogaster Gr43a (DmGr43a), a BmGr-9 ortholog, also responded to D-fructose, suggesting that DmGr43a relatives appear to compose the family of fructose receptors.
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