ArticleAntimicrobial agents and chemotherapy2011
Characterization of Salmonella enterica serovar Typhimurium isolates harboring a chromosomally encoded CMY-2 beta-lactamase gene located on a multidrug resistance genomic island.
Article in Antimicrobial agents and chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 37 citations in OpenAlex.
- mcr-1 remains detectable in various Escherichia coli lineages isolated from healthy swine after withdrawal of colistin use on the farm.The Journal of veterinary medical science · 2023Article
- Emergence of Tigecycline and Carbapenem-ResistantInfection and drug resistance · 2023Article
- Characterization of extended-spectrum cephalosporins and fluoroquinolone resistance of aFrontiers in microbiology · 2022Article
- Transmission of extended-spectrum cephalosporin-resistant Salmonella harboring a blaThe Journal of veterinary medical science · 2021Article
- Research Note: Longitudinal monitoring of chicken houses in a commercial layer farm for antimicrobial resistance in Escherichia coli with special reference to plasmid-mediated quinolone resistance.Poultry science · 2020Article
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- Genomic Sequence Analysis of the Multidrug-Resistance Region of AvianMicroorganisms · 2019Article
- Genotypic and phenotypic characterization of Salmonella enterica subsp. enterica serovar Typhimurium monophasic variants isolated in Thailand and Japan.The Journal of veterinary medical science · 2018Article
- Whole genome analyses of CMY-2-producing Escherichia coli isolates from humans, animals and food in Germany.BMC genomics · 2018Article
- Phylogenetic Characterization of Salmonella enterica Serovar Typhimurium and Its Monophasic Variant Isolated from Food Animals in Japan Revealed Replacement of Major Epidemic Clones in the Last 4 Decades.Journal of clinical microbiology · 2018Article
- Corrected Genome Annotations Reveal Gene Loss and Antibiotic Resistance as Drivers in the Fitness Evolution of Salmonella enterica Serovar Typhimurium.Journal of bacteriology · 2016Article
- Distribution and Relationships of Antimicrobial Resistance Determinants among Extended-Spectrum-Cephalosporin-Resistant or Carbapenem-Resistant Escherichia coli Isolates from Rivers and Sewage Treatment Plants in India.Antimicrobial agents and chemotherapy · 2016Article
- Whole-genome sequencing targets drug-resistant bacterial infections.Human genomics · 2015Review
- Two novel CMY-2-type β-lactamases encountered in clinical Escherichia coli isolates.Annals of clinical microbiology and antimicrobials · 2015Article
- Increase in resistance to extended-spectrum cephalosporins in Salmonella isolated from retail chicken products in Japan.PloS one · 2015Article
- Chromosome-mediated multidrug resistance in Salmonella enterica serovar Typhi.Antimicrobial agents and chemotherapy · 2015Article
- Extensive amplification of GI-VII-6, a multidrug resistance genomic island of Salmonella enterica serovar Typhimurium, increases resistance to extended-spectrum cephalosporins.Frontiers in microbiology · 2015Article
- Article
- Whole-Genome Sequence of CMY-2 β-Lactamase-Producing Salmonella enterica Serovar Typhimurium Strain L-3553.Genome announcements · 2014Article
- Salmonella pathogenicity and host adaptation in chicken-associated serovars.Microbiology and molecular biology reviews : MMBR · 2013Review
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since 2004, extended-spectrum cephalosporin (ESC)-resistant Salmonella enterica serovar Typhimurium (S. Typhimurium) isolates have been detected from cattle in the northern major island of Japan, Hokkaido. Resistance to ESCs was found to be mediated by CMY-2 type β-lactamase among 22 epidemiologically unrelated isolates showing indistinguishable pulsed-field gel electrophoresis patterns. Southern blot analysis using I-CeuI-digested genomic DNA demonstrated that the CMY-2 β-lactamase gene (bla(CMY-2)) was integrated in a 2.5-Mb chromosomal fragment. Genetic analysis of S. Typhimurium isolate L-3553 indicated that bla(CMY-2) was located on a unique 125-kb genomic island, GI-VII-6, which consists of 140 open reading frames. Pairwise alignment of GI-VII-6 and Escherichia coli plasmid pAR060302 (size, 167 kb) revealed that a large proportion of GI-VII-6 (99%) shows a high sequence similarity (>99%) with pAR060302. GI-VII-6 contains 11 antimicrobial resistance genes including sul1, qacEΔ1, aadA2, and dfrA12 in the aadA2 region; sugE1 and bla(CMY-2) in the bla(CMY-2) region; and sul2, strA, strB, tet(A), and floR in the floR region. Two directly repeated IS26 copies were present at both ends of GI-VII-6. Junction regions of GI-VII-6 were flanked by an 8-bp direct repeat, indicating that GI-VII-6 was acquired by transposition involving IS26 transposase. PCR scanning revealed that the overall structure of GI-VII-6 was almost identical in the 22 isolates. Phylogenetic analysis suggested that S. Typhimurium isolates harboring GI-VII-6 belong to a different genomic lineage than other whole-genome-sequenced S. Typhimurium strains. These data indicate that a particular clone of S. Typhimurium harboring GI-VII-6 has spread among the cattle population in Hokkaido, Japan.
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