Trial reportCirculation2011
Saphenous vein grafts with multiple versus single distal targets in patients undergoing coronary artery bypass surgery: one-year graft failure and five-year outcomes from the Project of Ex-Vivo Vein Graft Engineering via Transfection (PREVENT) IV trial.
Trial report in Circulation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05129228 (Intraoperative Optical Coherence Tomography of the Saphenous Vein Conduit in Patients Undergoing Coronary Artery Bypass Surgery), which is not on this map. Cited by 34 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intraoperative Optical Coherence Tomography of the Saphenous Vein Conduit in Patients Undergoing Coronary Artery Bypass Surgery
Who cites it
34 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Patency and adverse outcomes of sequential vs. individual saphenous vein grafts in coronary artery bypass: A meta-analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data.European heart journal · 2021Pooled it
- The patency of graft and anastomoses in sequential and individual coronary artery bypass grafting: A meta-analysis.Anatolian journal of cardiology · 2020Pooled it
- Development of a risk score for early saphenous vein graft failure: An individual patient data meta-analysis.The Journal of thoracic and cardiovascular surgery · 2020Pooled it
- Outcome Reporting in Cardiac Surgery Trials: Systematic Review and Critical Appraisal.Journal of the American Heart Association · 2015Pooled it
- Saphenous vein graft failure after coronary artery bypass surgery: insights from PREVENT IV.Circulation · 2014Trial
- HDL-Adjusted Inflammatory Ratios and Sequential Graft Configuration are Associated with Mid-Term Saphenous Vein Graft Occlusion in a Post-CABG Angiography Cohort.Journal of inflammation research · 2026Article
- Review
- Ticagrelor combined with aspirin may improve patency of vein graft one year after off-pump coronary artery bypass grafting: a single-center, randomized double-blinded clinical controlled trial.Frontiers in cardiovascular medicine · 2025Article
- Influence of graft anastomosis and graft morphology on long-term patency of the saphenous vein after aortocoronary bypass.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2024Article
- The left axillary artery is a reasonable option as the inflow site for saphenous vein graft in minimally invasive coronary artery bypass grafting.Frontiers in cardiovascular medicine · 2024Article
- Angiographic Outcomes for Arterial and Venous Conduits Used in CABG.Journal of clinical medicine · 2023Review
- Delivery of rivaroxaban and chitosan rapamycin microparticle with dual antithrombosis and antiproliferation functions inhibits venous neointimal hyperplasia.Drug delivery · 2022Article
- Long-Term Patency of Venous Conduits Targeting the Right Coronary Artery System-Single Is Superior to Sequential bypass Grafting.Journal of cardiovascular development and disease · 2022Article
- Coronary Artery Bypass: Review of Surgical Techniques and Impact on Long-Term Revascularization Outcomes.Cardiology and therapy · 2021Review
- Patency of conduits in patients who received internal mammary artery, radial artery and saphenous vein grafts.BMC cardiovascular disorders · 2020Observational
- Radial Artery Versus Saphenous Vein Grafts in Coronary Artery Bypass Surgery: a Literature Review.Current cardiology reports · 2019Review
- Management of Saphenous Vein Graft Disease in Patients with Prior Coronary Artery Bypass Surgery.Current treatment options in cardiovascular medicine · 2019Review
- A review of hybrid coronary revascularization.Indian journal of thoracic and cardiovascular surgery · 2018Review
- The radial artery in coronary surgery, 2018.Indian journal of thoracic and cardiovascular surgery · 2018Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundLimited information exists on the intermediate-term graft patency and 5-year clinical outcomes of patients receiving saphenous vein grafts with multiple (m-SVG) versus single distal targets (s-SVG) during coronary artery bypass graft (CABG) surgery in the current era. METHODS AND
resultsWe studied the association of the use of m-SVG versus s-SVG conduits with 1-year SVG failure (defined as ≥75% angiographic stenosis) and 5-year clinical events (death; death or myocardial infarction [MI]; and death, MI, or revascularization) in 3014 patients undergoing their first CABG surgery enrolled in the Project of Ex-vivo Vein Graft Engineering via Transfection (PREVENT) IV. Of 3014 patients enrolled in PREVENT IV, 1045 (34.7%) had ≥1 m-SVGs during CABG. Vein graft failure at 1-year was higher for m-SVG compared with s-SVG (adjusted odds ratio 1.24, 95% confidence interval 1.03 to 1.48). At 5 years, the adjusted composite of death, MI (including perioperative MI), or revascularization (hazard ratio 1.15, 95% confidence interval 1.00 to 1.31) and death or MI (hazard ratio 1.21, 95% confidence interval 1.03 to 1.43) were significantly higher in patients receiving m-SVGs.
conclusionsIn patients undergoing first CABG surgery, the use of m-SVG was associated with a higher 1-year vein graft failure rate and trends toward worse clinical outcomes. Additional studies are needed to better understand the most appropriate conduit to improve long-term graft patency and clinical outcomes of patients undergoing CABG surgery. In the meantime, these data should encourage the use of s-SVG over m-SVG when feasible.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.