ArticleMolecular and cellular biology2011
A conditional mouse model for measuring the frequency of homologous recombination events in vivo in the absence of essential genes.
Article in Molecular and cellular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Fueling chromosomal gene diversification and artificial evolution with CRISPR.Genome biology · 2025Review
- Transgenic mice harboring direct repeat substrates reveal key underlying causes of homologous recombination in vivo.DNA repair · 2022Review
- Article
- Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation.Nature communications · 2016Article
- Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer.BioMed research international · 2016Review
- Genetic Manipulation of Homologous Recombination In Vivo Attenuates Intestinal Tumorigenesis.Cancer prevention research (Philadelphia, Pa.) · 2015Article
- A novel frameshift mutation in BLM gene associated with high sister chromatid exchanges (SCE) in heterozygous family members.Molecular biology reports · 2014Article
- ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair.PloS one · 2014Article
- Induction of homologous recombination following in utero exposure to DNA-damaging agents.DNA repair · 2013Article
- Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The ability to detect and repair DNA damage is crucial to the prevention of various diseases. Loss of function of genes involved in these processes is known to result in significant developmental defects and/or predisposition to cancer. One such DNA repair mechanism, homologous recombination, has the capacity to repair a wide variety of lesions. Knockout mouse models of genes thought to be involved in DNA repair processes are frequently lethal, making in vivo studies very difficult, if not impossible. Therefore, we set out to develop an in vivo conditional mouse model system to facilitate investigations into the involvement of essential genes in homologous recombination. To test our model, we measured the frequency of spontaneous homologous recombination using the pink-eyed unstable mouse model, in which we conditionally excised either Blm or full-length Brca1 (breast cancer 1, early onset). These two genes are hypothesized to have opposing roles in homologous recombination. In summary, our in vivo data supports in vitro studies suggesting that BLM suppresses homologous recombination, while full-length BRCA1 promotes this process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.