ArticleThe Journal of experimental medicine2011
CIN85 drives B cell responses by linking BCR signals to the canonical NF-kappaB pathway.
Article in The Journal of experimental medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Article
- Curcumin alleviates experimental colitisWorld journal of gastroenterology · 2022Article
- B- and T-Cell Subset Abnormalities in Monogenic Common Variable Immunodeficiency.Frontiers in immunology · 2022Review
- Cracking the Monoubiquitin Code of Genetic Diseases.International journal of molecular sciences · 2020Review
- Identification and characterisation of a Theileria annulata proline-rich microtubule and SH3 domain-interacting protein (TaMISHIP) that forms a complex with CLASP1, EB1, and CD2AP at the schizont surface.Cellular microbiology · 2018Article
- Germline deletion of CIN85 in humans with X chromosome-linked antibody deficiency.The Journal of experimental medicine · 2018Article
- The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection.PLoS pathogens · 2018Article
- Mechanisms of central tolerance for B cells.Nature reviews. Immunology · 2017Review
- Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program.Genes & development · 2016Article
- LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation.Scientific reports · 2016Article
- Exome Sequencing Identifies Pathogenic and Modifier Mutations in a Child With Sporadic Dilated Cardiomyopathy.Journal of the American Heart Association · 2015Article
- CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface.The Journal of cell biology · 2015Article
- Sprouty1 induces a senescence-associated secretory phenotype by regulating NFκB activity: implications for tumorigenesis.Cell death and differentiation · 2014Article
- Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85.The EMBO journal · 2011Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CIN85, an adaptor protein which binds the C-terminal domain of tyrosine phosphorylated Cbl and Cbl-b, has been thought to be involved in the internalization and subsequent degradation of receptors. However, its physiological function remains unclear. To determine its role in B cells, we used Mb1-cre to generate mice with a B cell-specific deletion of CIN85. These mice had impaired T cell-independent type II antibody responses in vivo and diminished IKK-β activation and cellular responses to B cell receptor (BCR) cross-linking in vitro. Introduction of a constitutively active IKK-β construct corrected the defective antibody responses as well as cellular responses in the mutant mice. Together, our results suggest that CIN85 links the BCR to IKK-β activation, thereby contributing to T cell-independent immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.