Evidence map›Paper›PMID 21708823›Full record

Trial reportGut2011

Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss.

Kate Hallsworth, Gulnar Fattakhova, Kieren G Hollingsworth, Christian Thoma, Sarah Moore, Roy Taylor, Christopher P Day, Michael I Trenell

5 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Gut, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 233 papers, 23 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
233citing papers in PubMed, 23 pooled it
18.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02258126 nacompletednot on this mapstarted 2014, after this paper: background citation

The Effect of Exercise on Hepatic Fat in Overweight Children; the EFIGRO Study

TypeinterventionalSponsorUniversity of the Basque Country (UPV/EHU)Ran2014 to 2018Enrolled115ConditionsNon-alcoholic Fatty Liver Disease, Obesity, Metabolic SyndromeArmsMultidisciplinary intervention program
NCT02679417 nacompletednot on this mapstarted 2015, after this paper: background citation

The Effects of Type of Exercise on Hepatic Fat Content and Metabolic Profiles in Non-alcoholic Fatty Liver Disease: A Randomized Trial

TypeinterventionalSponsorMahidol UniversityRan2015 to 2016Enrolled38ConditionsNon-alcoholic Fatty Liver DiseaseArmsexercise
NCT03281083 phase2terminatednot on this mapstarted 2014, after this paper: background citation

Effects of 4-month Therapy of Levothyroxine on Non-Alcoholic Fatty Liver Disease (NAFLD) and Diabetes Control in Diabetic Patients

TypeinterventionalSponsorDuke-NUS Graduate Medical SchoolRan2014 to 2016Enrolled29ConditionsNon-Alcoholic Fatty Liver Disease, Diabetes Mellitus, Type 2ArmsLevothyroxine Sodium
NCT03875625 narecruitingnot on this mapstarted 2019, after this paper: background citation

Change of Adipose Tissues and Triglyceride in Obese Patients With Non-alcoholic Fatty Liver Disease After Bariatric Surgery or Life-style Intervention

TypeinterventionalSponsorChinese University of Hong KongRan2019 to 2026Enrolled80ConditionsNon-Alcoholic Fatty Liver Disease, Obesity, Morbid, Brown Fat, Metabolic DiseaseArmsBariatric surgery, Dietitian led life style modification intervention, Conventional care (control)
NCT07484776 naactive not recruitingnot on this mapstarted 2026, after this paper: background citation

Metabolic Flexibility in Patients With Early Triple-negative Breast Cancer and the Possible Effect of a Physical Exercise Intervention

TypeinterventionalSponsorUniversidad Europea de MadridRan2026 to 2028Enrolled40ConditionsTriple-Negative Breast Cancer (TNBC)ArmsCardiovascular training at maximal fat oxidation (FATmax), Cardiovascular training at maximal aerobic power (MAP), Resistance training
3 · Its place in the literature

Who cites it

233 citing papers in PubMed, 23 syntheses or guidelines pooled it, 506 citations in OpenAlex.

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173 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kate HallsworthInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK2NIHR Biomedical Research Centre for Ageing and Age-related Disease, Newcastle University, Newcastle upon Tyne, UK.
Gulnar Fattakhova
Kieren G Hollingsworth
Christian Thoma
Sarah Moore
Roy Taylor
Christopher P Day
Michael I Trenell
NIHR Newcastle Biomedical Research Centre · GBNewcastle University · GB

Funding

Medical Research Council G0900686Medical Research Council MC_G0802536
6 · The paper itself

Abstract

backgroundLifestyle interventions focusing on weight loss remain the cornerstone of non-alcoholic fatty liver disease (NAFLD) management. Despite this, the weight losses achieved in research trials are not easily replicated in the clinic and there is an urgent need for therapies independent of weight loss. Aerobic exercise is not well sustained and the effectiveness of the better tolerated resistance exercise upon liver lipid and mediators of liver lipid has not been assessed.

methodsSedentary adults with clinically defined NAFLD were assigned to 8 weeks of resistance exercise (n=11) or continued normal treatment (n=8).

results8 weeks of resistance exercise elicited a 13% relative reduction in liver lipid (14.0 ± 9.1 vs. 12.2 ± 9.0; p<0.05). Lipid oxidation (submaximal RQ -0.020 ± 0.010 vs. -0.004 ± 0.003; p<0.05), glucose control (-12% vs. +12% change AUC; p<0.01) and homeostasis model assessment insulin resistance (5.9 ± 5.9 to 4.6 ± 4.6 vs. 4.7 ± 2.1 to 5.1 ± 2.5; p<0.05) were all improved. Resistance exercise had no effect on body weight, visceral adipose tissue volume, or whole body fat mass (p>0.05).

conclusionThis is the first study to demonstrate that resistance exercise specifically improves NAFLD independent of any change in body weight. These data demonstrate that resistance exercise may provide benefit for the management for non-alcoholic fatty liver, and the long-term impact of this now requires evaluation.

Indexed as

AdultAgedAnthropometryBlood GlucoseBody CompositionExercise TestFatty Acids, NonesterifiedFatty LiverFemaleHumansLipid MetabolismLipidsLiverMaleMiddle AgedMotor ActivityBlood GlucoseFatty Acids, NonesterifiedLipids

Identifiers

PMID21708823
PMCPMC3152868
OpenAlexW2131294862

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.