SynthesisEnvironmental health perspectives2011
A meta-analysis of asbestos and lung cancer: is better quality exposure assessment associated with steeper slopes of the exposure-response relationships?
Synthesis in Environmental health perspectives, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Occupational Benzene Exposure and Lung Cancer in Human Studies: A Systematic Review and Meta-Analysis.Environmental health perspectives · 2024Pooled it
- Occupational Asbestos Exposure and Kidney Cancer: Systematic Review and Meta-analysis of Cohort Studies.Annals of work exposures and health · 2021Pooled it
- Exposure-response estimates for diesel engine exhaust and lung cancer mortality based on data from three occupational cohorts.Environmental health perspectives · 2014Pooled it
- Fiber burden and asbestos-related diseases: an umbrella review.Gaceta sanitariaPooled it
- Updates on exposure estimation for the Québec cohort of chrysotile miners and millers: implications for risk assessment and threshold hypothesis.Frontiers in public health · 2025Article
- Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments.EFSA journal. European Food Safety Authority · 2024Article
- Asbestos and disease - a public health success story?Scandinavian journal of work, environment & health · 2024Review
- Asbestos burden in lungs of non-occupationally exposed women from Broni (Pavia, Italy): a postmortem SEM-EDS study.Journal of thoracic disease · 2023Article
- International expert consensus on diagnosis and treatment of lung cancer complicated by chronic obstructive pulmonary disease.Translational lung cancer research · 2023Review
- Prediction of Asbestos-Related Diseases (ARDs) and Chrysotile Asbestos Exposure Concentrations in Asbestos-Cement (AC) Manufacturing Factories in Zimbabwe.International journal of environmental research and public health · 2022Article
- Epidemiology beyond its limits.Science advances · 2022Article
- Sex-Specific Mortality from Asbestos-Related Diseases, Lung and Ovarian Cancer in Municipalities with High Asbestos Consumption, Brazil, 2000-2017.International journal of environmental research and public health · 2022Article
- Comparison of Asbestos Victim Relief Available Outside of Conventional Occupational Compensation Schemes.International journal of environmental research and public health · 2021Article
- Reconstruction of the Korean Asbestos Job Exposure Matrix.Safety and health at work · 2021Article
- Ongoing downplaying of the carcinogenicity of chrysotile asbestos by vested interests.Journal of occupational medicine and toxicology (London, England) · 2021Article
- A Quantitative Retrospective Exposure Assessment for Former Chrysotile Asbestos Miners and Millers from Baie Verte, NL, Canada.Annals of work exposures and health · 2021Article
- Risk of Bias Assessments and Evidence Syntheses for Observational Epidemiologic Studies of Environmental and Occupational Exposures: Strengths and Limitations.Environmental health perspectives · 2020Article
- Draft for internal testing Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments.EFSA journal. European Food Safety Authority · 2020Article
- International Inventory of Occupational Exposure Information: OMEGA-NET.Annals of work exposures and health · 2020Article
- The disease burden attributable to 18 occupational risks in China: an analysis for the global burden of disease study 2017.Environmental health : a global access science source · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsbestos is a well-recognized cause of lung cancer, but there is considerable between-study heterogeneity in the slope of the exposure-response relationship.
objectiveWe considered the role of quality of the exposure assessment to potentially explain heterogeneity in exposure-response slope estimates. DATA SOURCES: We searched PubMed MEDLINE (1950-2009) for studies with quantitative estimates of cumulative asbestos exposure and lung cancer mortality and identified 19 original epidemiological studies. One was a population-based case-control study, and the others were industry-based cohort studies. DATA EXTRACTION: Cumulative exposure categories and corresponding risks were abstracted. Exposure-response slopes [KL (lung cancer potency factor of asbestos)] were calculated using linear relative risk regression models. DATA SYNTHESIS: We assessed the quality of five exposure assessment aspects of each study and conducted random effects univariate and multivariate meta-regressions. Heterogeneity in exposure-response relationships was greater than expected by chance (I2 = 64%). Stratification by exposure assessment characteristics revealed that studies with well-documented exposure assessment, larger contrast in exposure, greater coverage of the exposure history by exposure measurement data, and more complete job histories had higher meta-KL values than did studies without these characteristics. The latter two covariates were most strongly associated with the KL value. Meta-KL values increased when we incrementally restricted analyses to higher-quality studies.
conclusionsThis meta-analysis indicates that studies with higher-quality asbestos exposure assessment yield higher meta-estimates of the lung cancer risk per unit of exposure. Potency differences for predominantly chrysotile versus amphibole asbestos-exposed cohorts become difficult to ascertain when meta-analyses are restricted to studies with fewer exposure assessment limitations.
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