ArticleTranslational research : the journal of laboratory and clinical medicine2011
Nutrient plasma levels achieved during treatment that reduces noise-induced hearing loss.
Article in Translational research : the journal of laboratory and clinical medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Increased vitamin plasma levels in Swedish military personnel treated with nutrients prior to automatic weapon training.Noise & healthTrial
- Unlocking the Power of Magnesium: A Systematic Review and Meta-Analysis Regarding Its Role in Oxidative Stress and Inflammation.Antioxidants (Basel, Switzerland) · 2025Review
- Frailty Syndrome and Oxidative Stress as Possible Links Between Age-Related Hearing Loss and Alzheimer's Disease.Frontiers in neuroscience · 2021Review
- An overview of occupational noise-induced hearing loss among workers: epidemiology, pathogenesis, and preventive measures.Environmental health and preventive medicine · 2020Review
- Article
- Antioxidants and Vasodilators for the Treatment of Noise-Induced Hearing Loss: Are They Really Effective?Frontiers in cellular neuroscience · 2020Article
- Use of the guinea pig in studies on the development and prevention of acquired sensorineural hearing loss, with an emphasis on noise.The Journal of the Acoustical Society of America · 2019Review
- Effect of Myricetin on the Prevention of Noise-Induced Hearing Loss-An Animal Model.Iranian journal of otorhinolaryngology · 2019Article
- Otoprotectants: From Research to Clinical Application.Seminars in hearing · 2019Review
- An Oral Combination of Vitamins A, C, E, and MgFrontiers in neuroscience · 2018Article
- Associations between dietary quality, noise, and hearing: data from the National Health and Nutrition Examination Survey, 1999-2002.International journal of audiology · 2014Article
- Assessment of nutrient supplement to reduce gentamicin-induced ototoxicity.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- Auditory and non-auditory effects of noise on health.Lancet (London, England) · 2014Review
- Evaluating D-methionine dose to attenuate oxidative stress-mediated hearing loss following overexposure to noise.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2013Article
- Nutrient-enhanced diet reduces noise-induced damage to the inner ear and hearing loss.Translational research : the journal of laboratory and clinical medicine · 2011Article
- Dietary supplement comprised of β-carotene, vitamin C, vitamin E, and magnesium: failure to prevent music-induced temporary threshold shift.Audiology and neurotology. ExtraArticle
- Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Hearing loss encompasses both temporary and permanent deficits. If temporary threshold shift (TTS) and permanent threshold shift (PTS) share common pathological mechanisms, then agents that reduce PTS also should reduce TTS. Several antioxidant agents have reduced PTS in rodent models; however, reductions in TTS have been inconsistent. This study first determined whether dietary antioxidants (beta-carotene and vitamins C and E) delivered in combination with magnesium (Mg) reliably increase plasma concentrations of the active agents. Then, additional manipulations tested the hypothesis that these nutrients reduce acute TTS insult in the first 24 h after loud sound as well as longer lasting changes in hearing measured up to 7 days postnoise. Saline or nutrients were administered to guinea pigs prior to and after noise exposure. Sound-evoked electrophysiological responses were measured before noise, with tests repeated 1-h postnoise, as well as 1-day, 3-days, 5-days, and 7-days postnoise. All subjects showed significant functional recovery; subjects treated with nutrients recovered more rapidly and had better hearing outcomes at early postnoise times as well as the final test time. Thus, this combination of nutrients, which produced significant increases in plasma concentrations of vitamins C and E and Mg, effectively reduced hearing loss at multiple postnoise times. These data suggest that free radical formation contributes to TTS as well as PTS insults and suggest a potential opportunity to prevent TTS in human populations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.