Evidence map›Paper›PMID 21708280›Full record

SynthesisMutation research

Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis.

Kshitij Srivastava, Anvesha Srivastava, Kiran Lata Sharma, Balraj Mittal

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Mutation research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 9 pooled it
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 9 syntheses or guidelines pooled it, 87 citations in OpenAlex.

  1. Pooled it
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  5. CYP1A1 polymorphism interactions with smoking status in oral cancer risk: evidence from epidemiological studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
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  7. Association between glutathione S-transferase M1 null genotype and risk of gallbladder cancer: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
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  12. Variability, Expression, and Methylation ofInternational journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Kshitij SrivastavaNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Anvesha SrivastavaDepartment of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, UP, India.
Kiran Lata SharmaDepartment of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, UP, India.
Balraj MittalDepartment of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, UP, India. Electronic address: balraj@sgpgi.ac.in.
Sanjay Gandhi Post Graduate Institute of Medical Sciences · INNational Human Genome Research Institute · US

Funding

Intramural NIH HHS Z99 HG999999
6 · The paper itself

Abstract

Gallbladder cancer (GBC) is the most frequent biliary tract malignancy. Wide variations in GBC incidence and familial and epidemiological data suggest involvement of a genetic component in its etiopathogenesis. A systematic review of genetic association studies in GBC was performed by applying a meta-analysis approach and systematically reviewing PubMed database using appropriate terms. Odds ratios (ORs) and 95% confidence intervals (CIs) were appropriately derived for each gene-disease association using fixed and random effect models. Meta-regression with population size and genotyping method was also performed. Study quality was assessed using a 10-point scoring system designed from published guidelines. Following a review of 44 published manuscripts and one unpublished report, 80 candidate gene variants and 173 polymorphisms were analyzed among 1046 cases and 2310 controls. Majority of studies were of intermediate quality. Four polymorphisms with >3 separate studies were included in the meta-analysis [OGG1 (rs1052133), TP53 (rs1042522), CYP1A1 (rs1048943) and GSTM1 null polymorphism]. The meta-analysis demonstrated no significant associations of any of the above polymorphisms with GBC susceptibility except TP53 (rs1042522) polymorphism. To conclude, existing candidate gene studies in GBC susceptibility have so far been insufficient to confirm any association. Future research should focus on a more comprehensive approach utilizing potential gene-gene, gene-environment interactions and high-risk haplotypes.

Indexed as

Gene Expression ProfilingGenetic Predisposition to DiseaseGallbladder NeoplasmsPolymorphism, GeneticRisk Factors

Identifiers

PMID21708280
PMCPMC3162044
OpenAlexW2016119722

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.