ReviewProgress in neurobiology2011
Beyond faithful conduction: short-term dynamics, neuromodulation, and long-term regulation of spike propagation in the axon.
Review in Progress in neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
98 citing papers in PubMed, 183 citations in OpenAlex.
- Modelling the memory of unmyelinated axons: Integration of a data-driven approach with physiological memory concept.The Journal of physiology · 2026Article
- CaInternational journal of molecular sciences · 2026Article
- Article
- Ectopic action potentials in regular spiking neurons in the anesthetized mouse.Journal of neurophysiology · 2026Article
- Distributional invariance and proportional scaling in axonal conduction.Biophysical journal · 2026Article
- Use-dependent regulation of the axonal action potential in parvalbumin-expressing interneurons.bioRxiv : the preprint server for biology · 2026Article
- Dynamics of excitability in axonal trees.Biophysical journal · 2026Article
- Chemical multiplexing in the nervous system: molecular architecture, functional stratification, and pathophysiological plasticity of neuropeptide-classical neurotransmitter cotransmission.Frontiers in molecular neuroscience · 2026Review
- Biophysical properties of the membrane influence spike initiation dynamics and neuronal excitability: a focus on Kv1 channels in myelinated axons.Proceedings. Biological sciences · 2025Review
- Constructive Neuroengineering of Crossing Multi-Neurite Wiring Using Modifiable Agarose Gel Platforms.Gels (Basel, Switzerland) · 2025Article
- KThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Membrane mechanics dictate axonal pearls-on-a-string morphology and function.Nature neuroscience · 2025Article
- Shaping dynamical neural computations using spatiotemporal constraints.Biochemical and biophysical research communications · 2024Review
- The influence of hyperpolarization-activated cation current on conduction delay and failure of action potentials along axon related to abnormal functions.Cognitive neurodynamics · 2024Article
- Targeting papez circuit for cognitive dysfunction- insights into deep brain stimulation for Alzheimer's disease.Heliyon · 2024Review
- Activity-Dependent Ectopic Spiking in Parvalbumin-Expressing Interneurons of the Neocortex.eNeuro · 2024Article
- Beyond a Transmission Cable-New Technologies to Reveal the Richness in Axonal Electrophysiology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Ectopic burst induced by blockade of axonal potassium channels on the mouse hippocampal mossy fiber.Frontiers in cellular neuroscience · 2024Article
- Thalamo-cortical evoked potentials during stimulation of the dentato-rubro-thalamic tract demonstrate synaptic filtering.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Article
- Modeling analysis of depolarization-assisted afterdischarge in hippocampal mossy fibers.Frontiers in neural circuits · 2024Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Most spiking neurons are divided into functional compartments: a dendritic input region, a soma, a site of action potential initiation, an axon trunk and its collaterals for propagation of action potentials, and distal arborizations and terminals carrying the output synapses. The axon trunk and lower order branches are probably the most neglected and are often assumed to do nothing more than faithfully conducting action potentials. Nevertheless, there are numerous reports of complex membrane properties in non-synaptic axonal regions, owing to the presence of a multitude of different ion channels. Many different types of sodium and potassium channels have been described in axons, as well as calcium transients and hyperpolarization-activated inward currents. The complex time- and voltage-dependence resulting from the properties of ion channels can lead to activity-dependent changes in spike shape and resting potential, affecting the temporal fidelity of spike conduction. Neural coding can be altered by activity-dependent changes in conduction velocity, spike failures, and ectopic spike initiation. This is true under normal physiological conditions, and relevant for a number of neuropathies that lead to abnormal excitability. In addition, a growing number of studies show that the axon trunk can express receptors to glutamate, GABA, acetylcholine or biogenic amines, changing the relative contribution of some channels to axonal excitability and therefore rendering the contribution of this compartment to neural coding conditional on the presence of neuromodulators. Long-term regulatory processes, both during development and in the context of activity-dependent plasticity may also affect axonal properties to an underappreciated extent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.