SynthesisBMC public health2011
Should chronic hepatitis B mothers breastfeed? a meta analysis.
Synthesis in BMC public health, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis of the association between gestational diabetes mellitus and chronic hepatitis B infection during pregnancy.BMC research notes · 2014Pooled it
- Hepatitis B Virus: Epidemiology, Prophylaxis, Therapy, Clinical Outcomes, and Novel Therapeutic Directions.Biomolecules · 2026Review
- Editorial Expression of Concern: Should chronic hepatitis B mothers breastfeed? A meta analysis.BMC public health · 2026Article
- Factors influencing breastfeeding failure in mothers with hepatitis B infection: a qualitative study.Frontiers in nutrition · 2026Article
- Factors associated with hepatitis B mother-to-child transmission in a national prevention program.Clinical and molecular hepatology · 2025Article
- A New Approach in the Early Electrochemical Diagnosis of Hepatitis B Virus Infection using Carbon-based Nanomaterials.Recent patents on nanotechnology · 2025Review
- The Efficacy of Post-Exposure Prophylaxis in Infants Born to HBsAg-Positive Mothers: A Single Center Experience in Saudi Arabia.Global pediatric health · 2024Article
- Viruses and Human Milk: Transmission or Protection?Advances in nutrition (Bethesda, Md.) · 2023Review
- Knowledge Gaps and Current Evidence Regarding Breastfeeding Issues in Mothers with Chronic Diseases.Nutrients · 2023Review
- Factors associated with non-compliance with breastfeeding recommendation: a retrospective survey in hepatitis B virus-infected mothers who had taken Nucleos(t)ide analogs during pregnancy.BMC pregnancy and childbirth · 2021Article
- Viral hepatitis and pregnancy.Nature reviews. Gastroenterology & hepatology · 2021Review
- ESHRE guideline: medically assisted reproduction in patients with a viral infection/disease.Human reproduction open · 2021Article
- Vaccination Coverage and Awareness of Hepatitis B Virus Among Healthcare Students at a University in Cyprus.Materia socio-medica · 2019Article
- Serological positive markers of hepatitis B virus in femoral venous blood or umbilical cord blood should not be evidence of in-utero infection among neonates.BMC infectious diseases · 2016Article
- [Efficacy of hepatitis B immunoprophylaxis in children at high risk of hepatitis B and risk factors for mother-to-child transmission of hepatitis B virus].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Article
- Hepatitis B virus epidemiology.Cold Spring Harbor perspectives in medicine · 2015Review
- High Level of HBV DNA Virus in the Breast Milk Seems not to Contraindicate Breastfeeding.Mediterranean journal of hematology and infectious diseases · 2015Article
- Effectiveness of prevention of mother-to-child transmission practice in three provinces of Southern China.Human vaccines & immunotherapeutics · 2015Article
- Individualized management of pregnant women with high hepatitis B virus DNA levels.World journal of gastroenterology · 2014Review
- A study of immunoprophylaxis failure and risk factors of hepatitis B virus mother-to-infant transmission.European journal of pediatrics · 2014Article
Corrections and comments
- Expression of concern
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatitis B virus (HBV) exists in the breast milk of chronic hepatitis B (CHB) mothers. The authors use a meta-analytic technique to quantify the evidence of an association between breastfeeding and risk of CHB infection among the infants vaccinated against HBV.
methodsLiterature search is performed up to 2010 on the relationship between infantile CHB infection within one-year follow up after immunization with the third-dose hepatitis B vaccine and breastfeeding. Two reviewers independently extract the data and evaluate the methodological quality. A random-effects model is employed to systematically combine the results of all included studies.
resultsBased on data from 32 studies, 4.32% (244/5650) of infants born of CHB mothers develop CHB infection. The difference in risk of the infection between breastfed and formula-fed infants (RD) is -0.8%, (95% confidence interval [CI]: -1.6%, 0.1%). Analysis of the data from 16 of the studies finds that RD for mothers who are positive for the HBeAg and/or the HBV DNA, 0.7% (95%CI: -2.0%, 3.5%), is similar to that for those who are negative for these infectivity markers, -0.5% (95%CI: -1.7%, 0.6%).
conclusionsBreast milk is infectious; yet, breastfeeding, even by mothers with high infectivity, is not associated with demonstrable risk of infantile CHB infection, provided that the infants have been vaccinated against HBV at birth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.