Trial reportBMC cardiovascular disorders2011
Erectile dysfunction, physical activity and metabolic syndrome: differences in markers of atherosclerosis.
Trial report in BMC cardiovascular disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01119404 (Hämeenlinna Metabolic Syndrome Research Program), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hämeenlinna Metabolic Syndrome Research Program (HMS): Surrogate Indicators for Atherosclerosis in Men With Metabolic Syndrome, Coronary Heart Disease and Controls
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Associations between body mass index, waist circumference and erectile dysfunction: a systematic review and META-analysis.Reviews in endocrine & metabolic disorders · 2020Pooled it
- Metabolic syndrome and risk for ED: a meta-analysis.International journal of impotence researchPooled it
- Benefits of movement-based Behaviors on improving erectile function in American men: a nationwide survey study.Sexual medicine · 2025Article
- Insights into modifiable risk factors of erectile dysfunction, a wide-angled Mendelian Randomization study.Journal of advanced research · 2024Article
- Exercise, Erectile Dysfunction and Co-Morbidities: "The Good, the Bad and the Ugly".Reviews in cardiovascular medicine · 2022Review
- Is the plasma endocan level a reliable predictor for the severity of erectile dysfunction?International urology and nephrology · 2018Article
- Physical Activity to Improve Erectile Function: A Systematic Review of Intervention Studies.Sexual medicine · 2018Review
- Usefulness of serum fetuin-A level as a marker of erectile dysfunction.International journal of impotence research · 2017Article
- Significance of serum endothelial cell specific molecule-1 (Endocan) level in patients with erectile dysfunction: a pilot study.International journal of impotence research · 2017Article
- Association of Hypertension With Erectile Function in Chronic Peripheral Arterial Insufficiency Patients.Journal of clinical medicine research · 2016Article
- Basic Science Evidence for the Link Between Erectile Dysfunction and Cardiometabolic Dysfunction.The journal of sexual medicine · 2015Review
- The association between physical activity and sexual dysfunction in patients with diabetes mellitus of European and South Asian origin: The Oxford Sexual Dysfunction Study.European journal of medical research · 2015Article
- Carotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndrome.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- What do most erectile dysfunction guidelines have in common? No evidence-based discussion or recommendation of heart-healthy lifestyle changes and/or Panax ginseng.Asian journal of andrology · 2012Review
- Low serum melatonin levels are associated with erectile dysfunction.International braz j urol : official journal of the Brazilian Society of UrologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundErectile dysfunction (ED), impaired arterial elasticity, elevated resting heart rate as well as increased levels of oxidized LDL and fibrinogen associate with future cardiovascular events. Physical activity is crucial in the prevention of cardiovascular diseases (CVD), while metabolic syndrome (MetS) comprises an increased risk for CVD events. The aim of this study was to assess whether markers of subclinical atherosclerosis are associated with the presence of ED and MetS, and whether physical activity is protective of ED.
methods57 MetS (51.3 ± 8.0 years) and 48 physically active (PhA) (51.1 ± 8.1 years) subjects participated in the study. ED was assessed by the International Index of Erectile Function (IIEF) questionnaire, arterial elasticity by a radial artery tonometer (HDI/PulseWave™ CR-2000) and circulating oxLDL by a capture ELISA immunoassay. Fibrinogen and lipids were assessed by validated methods. The calculation of mean daily energy expenditure of physical exercise was based on a structured questionnaire.
resultsED was more often present among MetS compared to PhA subjects, 63.2% and 27.1%, respectively (p < 0.001). Regular physical exercise at the level of > 400 kcal/day was protective of ED (OR 0.12, 95% CI 0.017-0.778, p = 0.027), whereas increased fibrinogen (OR 4.67, 95% CI 1.171-18.627, p = 0.029) and elevated resting heart rate (OR 1.07, 95% CI 1.003-1.138, p = 0.04) were independently associated with the presence of ED. In addition, large arterial elasticity (ml/mmHgx10) was lower among MetS compared to PhA subjects (16.6 ± 4.0 vs. 19.6 ± 4.2, p < 0.001), as well as among ED compared to non-ED subjects (16.7 ± 4.6 vs. 19.0 ± 3.9, p = 0.008). Fibrinogen and resting heart rate were highest and large arterial elasticity lowest among subjects with both MetS and ED.
conclusionsMarkers of subclinical atherosclerosis associated with the presence of ED and were most evident among subjects with both MetS and ED. Thus, especially MetS patients presenting with ED should be considered at high risk for CVD events. Physical activity, on its part, seems to be protective of ED.
trial registrationClinicalTrials.gov NCT01119404.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.