ArticleThe European journal of neuroscience2011
Perirhinal cortex lesions uncover subsidiary systems in the rat for the detection of novel and familiar objects.
Article in The European journal of neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Consumption of processed foods impairs memory function through dietary advanced glycation end-products.bioRxiv : the preprint server for biology · 2026Article
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- Hippocampus Oxytocin Signaling Promotes Prosocial Eating in Rats.Biological psychiatry · 2025Article
- Western diet consumption impairs memory function via dysregulated hippocampus acetylcholine signaling.Brain, behavior, and immunity · 2024Article
- Early- but not late-adolescent Western diet consumption programs for long-lasting memory impairments in male but not female rats.Appetite · 2024Article
- Early- but not late-adolescent Western diet consumption programs for long-lasting memory impairments in male but not female rats.bioRxiv : the preprint server for biology · 2023Article
- Western diet consumption impairs memory function via dysregulated hippocampus acetylcholine signaling.bioRxiv : the preprint server for biology · 2023Article
- Visual recognition in rhesus monkeys requires area TE but not TEO.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Involvement of the Postrhinal and Perirhinal Cortices in Microscale and Macroscale Visuospatial Information Encoding.Frontiers in behavioral neuroscience · 2020Article
- Neuroprotection of Tropical Fruit Juice Mixture via the Reduction of iNOS Expression and CRH Level inEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Article
- Dopamine neurons projecting to the posterior striatum reinforce avoidance of threatening stimuli.Nature neuroscience · 2018Article
- Gut vagal sensory signaling regulates hippocampus function through multi-order pathways.Nature communications · 2018Article
- Detecting and discriminating novel objects: The impact of perirhinal cortex disconnection on hippocampal activity patterns.Hippocampus · 2016Article
- Perirhinal cortex lesions impair tests of object recognition memory but spare novelty detection.The European journal of neuroscience · 2015Article
- Distinct roles of basal forebrain cholinergic neurons in spatial and object recognition memory.Scientific reports · 2015Article
- Perirhinal cortex lesions in rats: Novelty detection and sensitivity to interference.Behavioral neuroscience · 2015Article
- Advances in the behavioural testing and network imaging of rodent recognition memory.Behavioural brain research · 2015Review
- In search of a recognition memory engram.Neuroscience and biobehavioral reviews · 2015Review
- Impact of CRFR1 Ablation on Amyloid-β Production and Accumulation in a Mouse Model of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2015Article
Corrections and comments
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6 authors.
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Abstract
The present study compared the impact of perirhinal cortex lesions on tests of object recognition. Object recognition was tested directly by looking at the preferential exploration of novel objects over simultaneously presented familiar objects. Object recognition was also tested indirectly by presenting just novel objects or just familiar objects, and recording exploration levels. Rats with perirhinal cortex lesions were severely impaired at discriminating a novel object from a simultaneously presented familiar object (direct test), yet displayed normal levels of exploration to novel objects presented on their own and showed normal declines in exploration times for familiar objects that were repeatedly presented (indirect tests). This effective reduction in the exploration of familiar objects after perirhinal cortex lesions points to the sparing of some recognition mechanisms. This possibility led us to determine whether rats with perirhinal cortex lesions can overcome their preferential exploration deficits when given multiple object familiarisation trials prior to that same (familiar) object being paired with a novel object. It was found that after multiple familiarisation trials, objects could now successfully be recognised as familiar by rats with perirhinal cortex lesions, both following a 90-min delay (the longest delay tested) and when object recognition was tested in the dark after familiarisation trials in the light. These latter findings reveal: (i) the presumed recruitment of other regions to solve recognition memory problems in the absence of perirhinal cortex tissue; and (ii) that these additional recognition mechanisms require more familiarisation trials than perirhinal-based recognition mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.