Evidence map›Paper›PMID 21707668›Full record

ReviewFEMS microbiology reviews2012

The circadian clock of Neurospora crassa.

Christopher L Baker, Jennifer J Loros, Jay C Dunlap

Abstract readReview
In one paragraph

Review in FEMS microbiology reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Evidence thatbioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Origin of the clock inFrontiers in molecular biosciences · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Circadian regulation of metabolism across photosynthetic organisms.The Plant journal : for cell and molecular biology · 2023
    Review
  18. Review
  19. Review
  20. Article

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christopher L BakerDepartment of Genetics, Dartmouth Medical School, Hanover, NH, USA.
Jennifer J Loros
Jay C Dunlap

Funding

Tools for Functional Analysis and Cell BiologyP01GM068087 · NIGMS · DARTMOUTH COLLEGE · PI DUNLAP, JAY C. · 2004 to 2013
$19.3M
Molecular and Cellular Biology at DartmouthT32GM008704 · NIGMS · DARTMOUTH COLLEGE · PI COMPTON, DUANE A. · 1998 to 2018
$6.8M
Identification and Analysis of Circadian Clock-Controlled GenesR01GM083336 · NIGMS · DARTMOUTH COLLEGE · PI LOROS, JENNIFER J. · 2008 to 2015
$5.7M
GENETIC AND MOLECULAR DISSECTION OF THE NEUROSPORA CLOCKR01GM034985 · NIGMS · DARTMOUTH COLLEGE · PI DUNLAP, JAY C. · 1986 to 2015
$5.7M
GENETIC AND MOLECULAR DISSECTION OF THE NEUSPORA CLOCKR37GM034985 · NIGMS · DARTMOUTH COLLEGE · PI DUNLAP, JAY C · 1998 to 2007
$4.4M
NIGMS NIH HHS 5T32GM008704NIGMS NIH HHS GM083336NIGMS NIH HHS GM34985NIGMS NIH HHS GM68087NIGMS NIH HHS P01 GM068087NIGMS NIH HHS R01 GM034985NIGMS NIH HHS R01 GM083336NIGMS NIH HHS R37 GM034985NIGMS NIH HHS T32 GM008704
6 · The paper itself

Abstract

Circadian clocks organize our inner physiology with respect to the external world, providing life with the ability to anticipate and thereby better prepare for major fluctuations in its environment. Circadian systems are widely represented in nearly all major branches of life, except archaebacteria, and within the eukaryotes, the filamentous fungus Neurospora crassa has served for nearly half a century as a durable model organism for uncovering the basic circadian physiology and molecular biology. Studies using Neurospora have clarified our fundamental understanding of the clock as nested positive and negative feedback loops regulated through transcriptional and post-transcriptional processes. These feedback loops are centered on a limited number of proteins that form molecular complexes, and their regulation provides a physical explanation for nearly all clock properties. This review will introduce the basics of circadian rhythms, the model filamentous fungus N. crassa, and provide an overview of the molecular components and regulation of the circadian clock.

Indexed as

Circadian ClocksGene Expression Regulation, FungalNeurospora crassa

Identifiers

PMID21707668
PMCPMC3203324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.