Evidence map›Paper›PMID 21707482›Full record

ReviewAnti-cancer agents in medicinal chemistry2011

Ceramide transfer protein and cancer.

Luana Scheffer, Pralhada Rao Raghavendra, Jingjing Ma, Jairaj K Acharya

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Anti-cancer agents in medicinal chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Observational
  2. Ceramide Transfer Protein (CERT): An Overlooked Molecular Player in Cancer.International journal of molecular sciences · 2021
    Review
  3. Relevance of Membrane Contact Sites in Cancer Progression.Frontiers in cell and developmental biology · 2020
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Luana SchefferLaboratory of Cell and Developmental Signaling, National Cancer Institute Frederick, MD 21702, USA.
Pralhada Rao Raghavendra
Jingjing Ma
Jairaj K Acharya
National Cancer Institute · US

Funding

Sphingolipid Signaling in MammalsZIABC011187 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ACHARYA, JAIRAJ · 2009 to 2025
$15.9M
PHOSPHOLIPID AND SPHINGOLIPID SIGNALING IN DROSOPHILAZ01BC010331 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ACHARYA, JAIRAJ · 2000 to 2008
$1.9M
Intramural NIH HHS Z01 BC010331Intramural NIH HHS ZIA BC011187
6 · The paper itself

Abstract

Sphingolipids are important structural components of membranes, and play an equally important role in basic cellular processes as second messengers. Recently, sphingolipids are receiving increasing attention in cancer research. Ceramide is the central molecule that regulates sphingolipid metabolism forming the basic structural backbone of sphingolipids and the precursor of all complex sphingolipids. It is been proposed to be an important regulator of tumor cell death following exposure to stress stimuli. The increase or decrease of ceramide levels leading to change in sensitivity of cancer cells to stress stimuli provides support for a central role of ceramide signaling in cell death. In this review, we have focused on ceramide transfer protein (CERT) as a major regulator of ceramide flux in the cell.

Indexed as

AnimalsCeramidesHumansNeoplasmsProtein Serine-Threonine KinasesSphingolipidsCeramidesCERT1 protein, humanProtein Serine-Threonine KinasesSphingolipids

Identifiers

PMID21707482
PMCPMC7383471
OpenAlexW2045324051

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.