SynthesisMolecular biology reports2012
The association between the PTPN22 C1858T polymorphism and rheumatoid arthritis: a meta-analysis update.
Synthesis in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 4 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Association of HLA-G polymorphisms with systemic lupus erythematosus and correlation between soluble HLA‑G levels and the disease: a meta-analysis.Zeitschrift fur Rheumatologie · 2021Pooled it
- Associations between ERAP1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis.Clinical rheumatology · 2016Pooled it
- Meta-analysis of associations between functional HLA-G polymorphisms and susceptibility to systemic lupus erythematosus and rheumatoid arthritis.Rheumatology international · 2015Pooled it
- The association of SCGB3A2 polymorphisms with the risk of Graves' disease: a meta-analysis.Endocrine · 2014Pooled it
- The functional PTPN22 C1858T polymorphism confers risk for rheumatoid arthritis in patients from Central Mexico.Clinical rheumatology · 2016Article
- The intestinal microbiota: its role in health and disease.European journal of pediatrics · 2015Review
- Lessons from type 1 diabetes for understanding natural history and prevention of autoimmune disease.Rheumatic diseases clinics of North America · 2014Review
- Potential role of PTPN22 in ankylosing spondylitis, comment on: associations of the PTPN22 and CTLA-4 genetic polymorphisms with Taiwanese ankylosing spondylitis.Rheumatology international · 2014Article
- PTPN22 1858C>T gene polymorphism in patients with SLE: association with serological and clinical results.Molecular biology reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to determine whether the protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism confers susceptibility to rheumatoid arthritis (RA) in populations with different ethnicities. A meta-analysis was conducted on the PTPN22 C1858T polymorphism involving eighteen studies, which in total contained 20344 RA patients and 21828 controls. Meta-analysis revealed an association between the PTPN22 C1858T polymorphism T allele and RA in all subjects (odds ratio [OR] = 1.637, 95% confidence interval [CI] = 1.514-1.770, P < 0.001). After stratification by ethnicity, analysis indicated that the PTPN22 C1858T polymorphism T allele was significantly associated with RA in Europeans and Non-Europeans (OR = 1.587, 95% CI = 1.486-1.696, P < 0.001; OR = 1.748, 95% CI = 1.274-2.398, P < 0.001). Meta-analysis of the CT + TT genotype showed the same result patterns as that shown by the PTPN22 C1858T polymorphism T allele. Furthermore, a direct comparison between rheumatoid factor (RF)-positive and -negative subjects revealed a significant association with the T allele in RA patients with RF, but not in subjects without RF. In conclusion, this meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with RA susceptibility in different ethnic groups, especially in Europeans, and the PTPN22 C1858T polymorphism T allele is significantly more prevalent in RF-positive patents than in RF-negative patients.
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