ArticleMedical microbiology and immunology2012
Activation of MAPK/c-Fos induced responses in oral epithelial cells is specific to Candida albicans and Candida dubliniensis hyphae.
Article in Medical microbiology and immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 69 citations in OpenAlex.
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- Aspergillus fumigatus Drives Tissue Damage via Iterative Assaults upon Mucosal Integrity and Immune Homeostasis.Infection and immunity · 2023Article
- Candida albicans-induced activation of the TGF-β/Smad pathway and upregulation of IL-6 may contribute to intrauterine adhesion.Scientific reports · 2023Article
- The Role of Host and Fungal Factors in the Commensal-to-Pathogen Transition ofCurrent clinical microbiology reports · 2023Review
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- Divergent EGFR/MAPK-Mediated Immune Responses to ClinicalFrontiers in immunology · 2022Article
- Oral Epithelial Cells Distinguish betweenmSystems · 2021Article
- The Emerging Role of Mast Cells in Response to Fungal Infection.Frontiers in immunology · 2021Review
- The regulation of hyphae growth inVirulence · 2020Review
- Candidalysin Is a Potent Trigger of Alarmin and Antimicrobial Peptide Release in Epithelial Cells.Cells · 2020Article
- Vulvovaginal Candidiasis: A Current Understanding and Burning Questions.Journal of fungi (Basel, Switzerland) · 2020Review
- Second-Generation Antidiabetic Sulfonylureas Inhibit Candida albicans and Candidalysin-Mediated Activation of the NLRP3 Inflammasome.Antimicrobial agents and chemotherapy · 2020Article
- Candidalysin: discovery and function in Candida albicans infections.Current opinion in microbiology · 2019Review
- Candidalysin Is Required for Neutrophil Recruitment and Virulence During Systemic Candida albicans Infection.The Journal of infectious diseases · 2019Article
- Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor.Nature communications · 2019Article
- Article
- Candida parapsilosis: from Genes to the Bedside.Clinical microbiology reviews · 2019Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Oral epithelial cells detect the human pathogenic fungus Candida albicans via NF-κB and a bi-phasic mitogen-activated protein kinase (MAPK) signaling response. However, discrimination between C. albicans yeast and hyphal forms is mediated only by the MAPK pathway, which constitutes activation of the MAPK phosphatase MKP1 and the c-Fos transcription factor and is targeted against the hyphal form. Given that C. albicans is not the only Candida species capable of filamentation or causing mucosal infections, we sought to determine whether this MAPK/MKP1/c-Fos mediated response mechanism was activated by other pathogenic Candida species, including C. dubliniensis, C. tropicalis, C. parapsilosis, C. glabrata and C. krusei. Although all Candida species activated the NF-κB signaling pathway, only C. albicans and C. dubliniensis were capable of inducing MKP1 and c-Fos activation, which directly correlated with hypha formation. However, only C. albicans strongly induced cytokine production (G-CSF, GM-CSF, IL-6 and IL-1α) and cell damage. Candida dubliniensis, C. tropicalis and C. parapsilosis were also capable of inducing IL-1α and this correlated with mild cell damage and was dependent upon fungal burdens. Our data demonstrate that activation of the MAPK/MKP1/c-Fos pathway in oral epithelial cells is specific to C. dubliniensis and C. albicans hyphae.
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