ArticleCellular & molecular immunology2011
HMBOX1 negatively regulates NK cell functions by suppressing the NKG2D/DAP10 signaling pathway.
Article in Cellular & molecular immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Metabolomic analysis reveals the influence of HMBOX1 on RAW264.7 cells proliferation based on UPLC-MS/MS.BMC genomics · 2023Article
- Plasma-Enabled Smart Nanoexosome Platform as Emerging Immunopathogenesis for Clinical Viral Infection.Pharmaceutics · 2022Review
- Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Cancer-secreted exosomal miR-1468-5p promotes tumor immune escape via the immunosuppressive reprogramming of lymphatic vessels.Molecular therapy : the journal of the American Society of Gene Therapy · 2021Article
- WTAP promotes osteosarcoma tumorigenesis by repressing HMBOX1 expression in an mCell death & disease · 2020Article
- Article
- Inactivated Sendai virus particle upregulates cancer cell expression of intercellular adhesion molecule-1 and enhances natural killer cell sensitivity on cancer cells.Cancer science · 2017Article
- Exosomes mediate hepatitis B virus (HBV) transmission and NK-cell dysfunction.Cellular & molecular immunology · 2017Article
- Stochastic left-right neuronal asymmetry in Caenorhabditis elegans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Identification of high risk anaplastic gliomas by a diagnostic and prognostic signature derived from mRNA expression profiling.Oncotarget · 2015Article
- Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs.Molecular cancer · 2014Article
- Impaired NK cell antiviral cytokine response against influenza virus in small-for-gestational-age neonates.Cellular & molecular immunology · 2013Article
- The liver works as a school to educate regulatory immune cells.Cellular & molecular immunology · 2013Review
- Memory NK cells: why do they reside in the liver?Cellular & molecular immunology · 2013Review
- NK cell-based immunotherapy for malignant diseases.Cellular & molecular immunology · 2013Review
- NK cells in immunotolerant organs.Cellular & molecular immunology · 2013Review
- miR-30c-1* promotes natural killer cell cytotoxicity against human hepatoma cells by targeting the transcription factor HMBOX1.Cancer science · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HMBOX1 is a new member of the homeobox family. Homeobox members have been reported to participate in embryonic development and systemic metabolism, but the function of HMBOX1 remains unclear, especially in the hematopoietic system. Here, we show that HMBOX1 is expressed at a high level in primary human NK cells but is expressed at much lower levels in NK cell lines. Overexpression of HMBOX1 significantly inhibited NK cell activities, including natural cytotoxicity against tumor cells, the level of CD107a (a marker protein for degranulation) and the production of cytolytic proteins (perforin and granzymes). More interestingly, HMBOX1 negatively regulated the expression of NKG2D and the activation of the NKG2D/DAP10 signaling pathway in NK cells. This effect was reversed by knocking down HMBOX1. Taken together, these findings demonstrate that HMBOX1 may act as a negative regulator of NK cell functions via suppressing the NKG2D/DAP10 signaling pathway.
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