ArticleGenetics2011
A survey for novel imprinted genes in the mouse placenta by mRNA-seq.
Article in Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Conservation and divergence of canonical and non-canonical imprinting in murids.Genome biology · 2023Pooled it
- Pooled it
- Evolution of Gene Expression Across Functional Regions of the Mouse Placenta.Genome biology and evolution · 2026Article
- Article
- The molecular pathogenesis of placenta accreta spectrum disorder and its clinical applications.Archives of gynecology and obstetrics · 2025Review
- Dynamic allelic expression in mouse mammary glands across the adult developmental cycle.Nucleic acids research · 2025Article
- United by conflict: Convergent signatures of parental conflict in angiosperms and placental mammals.The Journal of heredity · 2024Review
- PRKACB is a novel imprinted gene in marsupials.Epigenetics & chromatin · 2024Article
- Marsupials have monoallelic MEST expression with a conserved antisense lncRNA but MEST is not imprinted.Heredity · 2024Article
- Origin and Evolution of Marsupial-specific Imprinting Clusters Through Lineage-specific Gene Duplications and Acquisition of Promoter Differential Methylation.Molecular biology and evolution · 2023Article
- Inference of putative cell-type-specific imprinted regulatory elements and genes during human neuronal differentiation.Human molecular genetics · 2023Article
- X chromosome-dependent disruption of placental regulatory networks in hybrid dwarf hamsters.Genetics · 2021Article
- ZFP57 dictates allelic expression switch of target imprinted genes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Review
- Landscape of genomic imprinting and its functions in the mouse mammary gland.Journal of molecular cell biology · 2020Article
- ISoLDE: a data-driven statistical method for the inference of allelic imbalance in datasets with reciprocal crosses.Bioinformatics (Oxford, England) · 2020Article
- Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues.Genome biology · 2019Article
- Article
- Technical advances contribute to the study of genomic imprinting.PLoS genetics · 2019Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many questions about the regulation, functional specialization, computational prediction, and evolution of genomic imprinting would be better addressed by having an exhaustive genome-wide catalog of genes that display parent-of-origin differential expression. As a first-pass scan for novel imprinted genes, we performed mRNA-seq experiments on embryonic day 17.5 (E17.5) mouse placenta cDNA samples from reciprocal cross F1 progeny of AKR and PWD mouse strains and quantified the allele-specific expression and the degree of parent-of-origin allelic imbalance. We confirmed the imprinting status of 23 known imprinted genes in the placenta and found that 12 genes reported previously to be imprinted in other tissues are also imprinted in mouse placenta. Through a well-replicated design using an orthogonal allelic-expression technology, we verified 5 novel imprinted genes that were not previously known to be imprinted in mouse (Pde10, Phf17, Phactr2, Zfp64, and Htra3). Our data suggest that most of the strongly imprinted genes have already been identified, at least in the placenta, and that evidence supports perhaps 100 additional weakly imprinted genes. Despite previous appearance that the placenta tends to display an excess of maternally expressed imprinted genes, with the addition of our validated set of placenta-imprinted genes, this maternal bias has disappeared.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.