ArticleGenetics2011
Ectopic gene expression and organogenesis in Arabidopsis mutants missing BRU1 required for genome maintenance.
Article in Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Functional characterization of TONSOKU in Cyathula officinalis reveals its role in DNA damage and root development.BMC plant biology · 2026Article
- TONSOKU prevents the formation of large tandem duplications and restrains ATR-WEE1 checkpoint activation.Nature communications · 2026Article
- The Role of the TSK/TONSL-H3.1 Pathway in Maintaining Genome Stability in Multicellular Eukaryotes.International journal of molecular sciences · 2022Review
- MGO3 and GIP1 act synergistically for the maintenance of centromeric cohesion.Nucleus (Austin, Tex.) · 2017Article
- Article
- DNA Damage Repair in the Context of Plant Chromatin.Plant physiology · 2015Review
- Article
- Epigenetic regulation in plants.Cold Spring Harbor perspectives in biology · 2014Review
- Heat-induced release of epigenetic silencing reveals the concealed role of an imprinted plant gene.PLoS genetics · 2014Article
- GIP/MZT1 proteins orchestrate nuclear shaping.Frontiers in plant science · 2014Review
- The GIP gamma-tubulin complex-associated proteins are involved in nuclear architecture in Arabidopsis thaliana.Frontiers in plant science · 2013Article
- Mutations in two non-canonical Arabidopsis SWI2/SNF2 chromatin remodeling ATPases cause embryogenesis and stem cell maintenance defects.The Plant journal : for cell and molecular biology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromatin reconstitution after DNA replication and repair is essential for the inheritance of epigenetic information, but mechanisms underlying such a process are still poorly understood. Previously, we proposed that Arabidopsis BRU1 functions to ensure the chromatin reconstitution. Loss-of-function mutants of BRU1 are hypersensitive to genotoxic stresses and cause release of transcriptional gene silencing of heterochromatic genes. In this study, we show that BRU1 also plays roles in gene regulation in euchromatic regions. bru1 mutations caused sporadic ectopic expression of genes, including those that encode master regulators of developmental programs such as stem cell maintenance and embryogenesis. bru1 mutants exhibited adventitious organogenesis, probably due to the misexpression of such developmental regulators. The key regulatory genes misregulated in bru1 alleles were often targets of PcG SET-domain proteins, although the overlap between the bru1-misregulated and PcG SET-domain-regulated genes was limited at a genome-wide level. Surprisingly, a considerable fraction of the genes activated in bru1 were located in several subchromosomal regions ranging from 174 to 944 kb in size. Our results suggest that BRU1 has a function related to the stability of subchromosomal gene regulation in the euchromatic regions, in addition to the maintenance of chromatin states coupled with heritable epigenetic marks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.